DegronMD

Uniprot ID: Q92545

Source protein: Transmembrane protein 131

Source gene: TMEM131

Class: DEG_APCC_DBOX_1

Location: 956:964

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9368

ASA_SCORE: 52

COIL: 0.4049

CONS_SCORE: 0.5262

DSS_SCORE: 0.1446

HELIX: 0.0134

FCONS_SCORE: 1.2092

RIG_SCORE: 0.8982

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R957K	TCGA-77-8148	LUSC	TCGA	VRNNLTVMD	DEG_APCC_DBOX_1	0.7237
p.R957K	DO26458	LUSC	ICGC	VRNNLTVMD	DEG_APCC_DBOX_1	0.7237
p.D964Y	TCGA-AP-A059	UCEC	TCGA	VRNNLTVMD	DEG_APCC_DBOX_1	0.6214
p.D964Y	DO41361	UCEC	ICGC	VRNNLTVMD	DEG_APCC_DBOX_1	0.6214
p.T974P	TCGA-EO-A3B0	UCEC	TCGA	VRNNLTVMD	DEG_APCC_DBOX_1	0.0556
p.T974P	DO219773	UCEC	ICGC	VRNNLTVMD	DEG_APCC_DBOX_1	0.0556
p.Q969L	DO228284	LICA	ICGC	VRNNLTVMD	DEG_APCC_DBOX_1	0.1944
p.M967I	SIDM01293	Colorectal Carcinoma	GDSC	VRNNLTVMD	DEG_APCC_DBOX_1	0.25
p.L960M	SIDM00228	Thyroid Gland Carcinoma	GDSC	VRNNLTVMD	DEG_APCC_DBOX_1	0.711
p.L960M	ACH-000897	Thyroid Cancer	CCLE	VRNNLTVMD	DEG_APCC_DBOX_1	0.711

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92545	Transmembrane protein 131	DEG_APCC_DBOX_1	956:964	VRNNLTVMD	APC,CDC20,FZR1	0.9368	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons