DegronMD

Uniprot ID: Q5T0Z8

Source protein: Uncharacterized protein C6orf132

Source gene: C6orf132

Class: DEG_APCC_DBOX_1

Location: 75:83

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8633

ASA_SCORE: 67.2

COIL: 0.8089

CONS_SCORE: 0.9658

DSS_SCORE: 0.3641

HELIX: 0.0398

FCONS_SCORE: 0.9709

RIG_SCORE: 0.8362

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R76Q	DO233272	GACA	ICGC	VRPLLTFLP	DEG_APCC_DBOX_1	0.7329
p.V75I	DO50970	LICA	ICGC	VRPLLTFLP	DEG_APCC_DBOX_1	0.5965
p.E88V	DO23366	LINC	ICGC	VRPLLTFLP	DEG_APCC_DBOX_1	0.1944
p.R76W	SIDM00216	Colorectal Carcinoma	GDSC	VRPLLTFLP	DEG_APCC_DBOX_1	0.8634
p.R76W	ACH-000989	Colon/Colorectal Cancer	CCLE	VRPLLTFLP	DEG_APCC_DBOX_1	0.8634
p.A67D	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	VRPLLTFLP	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T0Z8	Uncharacterized protein C6orf132	DEG_APCC_DBOX_1	75:83	VRPLLTFLP	APC,CDC20,FZR1	0.8633	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons