DegronMD

Uniprot ID: Q8N5U0

Source protein: Uncharacterized protein C11orf42

Source gene: C11orf42

Class: DEG_APCC_DBOX_1

Location: 226:234

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9551

ASA_SCORE: 70.7778

COIL: 0.7351

CONS_SCORE: 0.5255

DSS_SCORE: 0.4842

HELIX: 0.0263

FCONS_SCORE: 0.9275

RIG_SCORE: 0.7236

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P238R	TCGA-50-6590	LUAD	TCGA	VRPNLSIMP	DEG_APCC_DBOX_1	0.2222
p.P238R	DO24692	LUAD	ICGC	VRPNLSIMP	DEG_APCC_DBOX_1	0.2222
p.P228H	TCGA-86-8358	LUAD	TCGA	VRPNLSIMP	DEG_APCC_DBOX_1	0.6583
p.P228H	DO25471	LUAD	ICGC	VRPNLSIMP	DEG_APCC_DBOX_1	0.6583
p.N229D	TCGA-A6-6781	COAD	TCGA	VRPNLSIMP	DEG_APCC_DBOX_1	0.5821
p.N229D	DO8447	COAD	ICGC	VRPNLSIMP	DEG_APCC_DBOX_1	0.5821
p.V226I	TCGA-AP-A0LQ	UCEC	TCGA	VRPNLSIMP	DEG_APCC_DBOX_1	0.5965
p.V226I	DO42625	UCEC	ICGC	VRPNLSIMP	DEG_APCC_DBOX_1	0.5965
p.N224K	TCGA-G5-6233	READ	TCGA	VRPNLSIMP	DEG_APCC_DBOX_1	0.2778
p.N224K	DO36626	READ	ICGC	VRPNLSIMP	DEG_APCC_DBOX_1	0.2778
p.P220S	DO222427	BTCA	ICGC	VRPNLSIMP	DEG_APCC_DBOX_1	0.1667
p.P242S	DO229010	COCA	ICGC	VRPNLSIMP	DEG_APCC_DBOX_1	0.1111
p.P242S	DO229013	COCA	ICGC	VRPNLSIMP	DEG_APCC_DBOX_1	0.1111
p.P242S	DO229016	COCA	ICGC	VRPNLSIMP	DEG_APCC_DBOX_1	0.1111
p.P242S	DO229003	COCA	ICGC	VRPNLSIMP	DEG_APCC_DBOX_1	0.1111
p.P242S	DO229005	COCA	ICGC	VRPNLSIMP	DEG_APCC_DBOX_1	0.1111
p.P242S	DO228950	LICA	ICGC	VRPNLSIMP	DEG_APCC_DBOX_1	0.1111
p.K216E	ACH-000593	Bladder Cancer	CCLE	VRPNLSIMP	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5U0	Uncharacterized protein C11orf42	DEG_APCC_DBOX_1	226:234	VRPNLSIMP	APC,CDC20,FZR1	0.9551	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons