DegronMD

Uniprot ID: Q16623

Source protein: Syntaxin-1A

Source gene: STX1A

Class: DEG_APCC_DBOX_1

Location: 89:97

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6482

ASA_SCORE: 62.8333

COIL: 0.0236

CONS_SCORE: 0.469

DSS_SCORE: 0.4207

HELIX: 0.9777

FCONS_SCORE: 1.3537

RIG_SCORE: 0.7414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D81N	TCGA-E6-A1LX	UCEC	TCGA	VRSKLKSIE	DEG_APCC_DBOX_1	0.1111
p.D81N	DO41020	UCEC	ICGC	VRSKLKSIE	DEG_APCC_DBOX_1	0.1111
p.M79K	DO224664	COCA	ICGC	VRSKLKSIE	DEG_APCC_DBOX_1	0.0556
p.S99F	DO233867	GACA	ICGC	VRSKLKSIE	DEG_APCC_DBOX_1	0.7222
p.S95R	DO229029	LICA	ICGC	VRSKLKSIE	DEG_APCC_DBOX_1	0.6316
p.E101D	DO50940	LICA	ICGC	VRSKLKSIE	DEG_APCC_DBOX_1	0.2222
p.E103D	SIDM00217	Colorectal Carcinoma	GDSC	VRSKLKSIE	DEG_APCC_DBOX_1	0.1667
p.E103D	ACH-000999	Colon/Colorectal Cancer	CCLE	VRSKLKSIE	DEG_APCC_DBOX_1	0.1667
p.E103D	SNU-1040	large_intestine	COSMIC	VRSKLKSIE	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16623	Syntaxin-1A	DEG_APCC_DBOX_1	89:97	VRSKLKSIE	APC,CDC20,FZR1	0.6482	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons