DegronMD

Uniprot ID: Q7Z3J2

Source protein: VPS35 endosomal protein-sorting factor-like

Source gene: VPS35L

Class: DEG_APCC_DBOX_1

Location: 158:166

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9361

ASA_SCORE: 84.9667

COIL: 0.1446

CONS_SCORE: 0.5623

DSS_SCORE: 0.4488

HELIX: 0.8488

FCONS_SCORE: 1.589

RIG_SCORE: 0.8099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V154M	SIDM00167	Head and Neck Carcinoma	GDSC	VRTRLEELD	DEG_APCC_DBOX_1	0.2222
p.V163A	LS-180	large_intestine	COSMIC	VRTRLEELD	DEG_APCC_DBOX_1	0.6936
p.I162N	Sarc9371	bone	COSMIC	VRTRLEELD	DEG_APCC_DBOX_1	0.728
p.R159Q	TE-4	oesophagus	COSMIC	VRTRLEELD	DEG_APCC_DBOX_1	0.7329
p.G151R	TE-4	oesophagus	COSMIC	VRTRLEELD	DEG_APCC_DBOX_1	0.1389
p.E164A	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	VRTRLEELD	DEG_APCC_DBOX_1	0.659

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3J2	VPS35 endosomal protein-sorting factor-like	DEG_APCC_DBOX_1	158:166	VRTRLEELD	APC,CDC20,FZR1	0.9361	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons