DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 1697:1704

E3 ligase: FBXW7

DEGRON score: 0.5593

ASA_SCORE: 96.6375

COIL: 0.8959

CONS_SCORE: 0.5341

DSS_SCORE: 0.5015

HELIX: 0.0151

FCONS_SCORE: 0.8741

RIG_SCORE: 0.7789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1703T	TCGA-EM-A22O	THCA	TCGA	VRTTPVAS	DEG_SCF_FBW7_1	0.6028
p.A1703T	DO38911	THCA	ICGC	VRTTPVAS	DEG_SCF_FBW7_1	0.6028
p.P1701Q	TCGA-EO-A22X	UCEC	TCGA	VRTTPVAS	DEG_SCF_FBW7_1	0.7035
p.P1701Q	DO43907	UCEC	ICGC	VRTTPVAS	DEG_SCF_FBW7_1	0.7035
p.V1702A	TCGA-HU-A4GQ	STAD	TCGA	VRTTPVAS	DEG_SCF_FBW7_1	0.5825
p.V1702A	DO47767	STAD	ICGC	VRTTPVAS	DEG_SCF_FBW7_1	0.5825
p.T1713I	DO233964	BPLL	ICGC	VRTTPVAS	DEG_SCF_FBW7_1	0.0833
p.T1699I	DO48308	ESCA	ICGC	VRTTPVAS	DEG_SCF_FBW7_1	0.5966
p.P1701L	DO229052	LICA	ICGC	VRTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P1701L	DO22860	LIHC	ICGC	VRTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P1701S	DO222837	MELA	ICGC	VRTTPVAS	DEG_SCF_FBW7_1	0.6752
p.V1697A	SIDM01003	T-Lymphoblastic Leukemia	GDSC	VRTTPVAS	DEG_SCF_FBW7_1	0.6936
p.V1697A	ACH-000101	Leukemia	CCLE	VRTTPVAS	DEG_SCF_FBW7_1	0.6936
p.V1697A	KE-37	haematopoietic_and_lymphoid_tissue	COSMIC	VRTTPVAS	DEG_SCF_FBW7_1	0.6936
p.V1697F	ACH-000791	Lung Cancer	CCLE	VRTTPVAS	DEG_SCF_FBW7_1	0.7068
p.T1709I	ACH-000974	Endometrial/Uterine Cancer	CCLE	VRTTPVAS	DEG_SCF_FBW7_1	0.1944
p.T1709I	SNG-M	endometrium	COSMIC	VRTTPVAS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1697:1704	VRTTPVAS	FBXW7	0.5593	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons