DegronMD

Uniprot ID: Q9BXM0

Source protein: Periaxin

Source gene: PRX

Class: DEG_APCC_DBOX_1

Location: 1374:1382

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8967

ASA_SCORE: 69.7667

COIL: 0.6343

CONS_SCORE: 0.8592

DSS_SCORE: 0.5576

HELIX: 0.0164

FCONS_SCORE: 1.0018

RIG_SCORE: 0.7271

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1375L	TCGA-D3-A2JL	SKCM	TCGA	VRVRLPRVG	DEG_APCC_DBOX_1	0.8428
p.R1375L	DO47278	SKCM	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.8428
p.A1385T	TCGA-E6-A2P9	UCEC	TCGA	VRVRLPRVG	DEG_APCC_DBOX_1	0.25
p.A1385T	DO43714	UCEC	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.25
p.R1371W	TCGA-ER-A19P	SKCM	TCGA	VRVRLPRVG	DEG_APCC_DBOX_1	0.25
p.R1371W	DO34600	PACA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.25
p.R1371W	DO47623	SKCM	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.25
p.R1391Q	TCGA-FU-A3HZ	CESC	TCGA	VRVRLPRVG	DEG_APCC_DBOX_1	0.0833
p.R1391Q	DO6308	CESC	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.0833
p.R1373Q	DO222436	BTCA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.3056
p.R1373Q	DO229376	BTCA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.3056
p.R1373Q	DO233712	GACA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.3056
p.R1370H	DO234366	ESAD	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.2222
p.R1370H	DO233882	GACA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.2222
p.R1380C	DO233869	GACA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.719
p.R1377C	DO229036	LICA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.719
p.S1387F	DO220891	MELA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.1944
p.S1387F	DO222542	MELA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.1944
p.A1367T	DO232761	PBCA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	0.1389
p.R1380H	SIDM02069	Colorectal Carcinoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	0.7133
p.R1380H	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	0.7133
p.R1370S	SIDM00683	Prostate Carcinoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	0.2222
p.R1370S	SIDM01397	Melanoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	0.2222
p.R1370S	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	0.2222
p.R1370S	LNCaP-Clone-FGC	prostate	COSMIC	VRVRLPRVG	DEG_APCC_DBOX_1	0.2222
p.R1370C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	0.2222
p.R1370C	ACH-000981	Leukemia	CCLE	VRVRLPRVG	DEG_APCC_DBOX_1	0.2222
p.R1370C	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VRVRLPRVG	DEG_APCC_DBOX_1	0.2222
p.S1387C	SIDM00893	Breast Carcinoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	0.1944
p.S1387C	ACH-000536	Breast Cancer	CCLE	VRVRLPRVG	DEG_APCC_DBOX_1	0.1944
p.S1387C	BT-20	breast	COSMIC	VRVRLPRVG	DEG_APCC_DBOX_1	0.1944
p.R1391W	SIDM00420	Bladder Carcinoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	0.0833
p.R1391W	ACH-000566	Bladder Cancer	CCLE	VRVRLPRVG	DEG_APCC_DBOX_1	0.0833
p.R1391W	SW1710	urinary_tract	COSMIC	VRVRLPRVG	DEG_APCC_DBOX_1	0.0833
p.R1373G	SIDM00006	Other Solid Cancers	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	0.3056
p.R1373G	ACH-001552	Skin Cancer	CCLE	VRVRLPRVG	DEG_APCC_DBOX_1	0.3056
p.R1373G	MCC26	skin	COSMIC	VRVRLPRVG	DEG_APCC_DBOX_1	0.3056
p.G1372V	SIDM01577	Plasma Cell Myeloma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRVRLPRVG

Degron related mutations and impact score

Drug responses associated with PRX mutations

All proteins holding degron of VRVRLPRVG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXM0	Periaxin	DEG_APCC_DBOX_1	1374:1382	VRVRLPRVG	APC,CDC20,FZR1	0.8967	More...