DegronMD

Uniprot ID: O95394

Source protein: Phosphoacetylglucosamine mutase

Source gene: PGM3

Class: LIG_APCC_ABBA_1

Location: 504:509

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5341

ASA_SCORE: 25.65

COIL: 0.0227

CONS_SCORE: 0.8611

DSS_SCORE: 0.4115

HELIX: 0.0025

FCONS_SCORE: 1.221

RIG_SCORE: 0.8535

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D511Y	TCGA-AA-3984	COAD	TCGA	VRVYAE	LIG_APCC_ABBA_1	0.2778
p.D511Y	DO9002	COAD	ICGC	VRVYAE	LIG_APCC_ABBA_1	0.2778
p.K515R	TCGA-DI-A1BU	UCEC	TCGA	VRVYAE	LIG_APCC_ABBA_1	0.1667
p.K515R	DO42023	UCEC	ICGC	VRVYAE	LIG_APCC_ABBA_1	0.1667
p.G504V	TCGA-EO-A22R	UCEC	TCGA	VRVYAE	LIG_APCC_ABBA_1	0.7532
p.D494V	TCGA-HP-A5N0	LIHC	TCGA	VRVYAE	LIG_APCC_ABBA_1	0.0556
p.R496W	DO233858	GACA	ICGC	VRVYAE	LIG_APCC_ABBA_1	0.1111
p.R496W	DO13522	GBM	ICGC	VRVYAE	LIG_APCC_ABBA_1	0.1111
p.V504I	DO233942	GACA	ICGC	VRVYAE	LIG_APCC_ABBA_1	0.5965
p.H518N	DO229015	LICA	ICGC	VRVYAE	LIG_APCC_ABBA_1	0.0833
p.P503L	SIDM00296	Small Cell Lung Carcinoma	GDSC	VRVYAE	LIG_APCC_ABBA_1	0.3056
p.P503L	LU-134-A	lung	COSMIC	VRVYAE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95394	Phosphoacetylglucosamine mutase	LIG_APCC_ABBA_1	504:509	VRVYAE	APC,CDC20,FZR1	0.5341	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons