DegronMD

Uniprot ID: Q7Z3T8

Source protein: Zinc finger FYVE domain-containing protein 16

Source gene: ZFYVE16

Class: DEG_SCF_FBW7_1

Location: 169:176

E3 ligase: FBXW7

DEGRON score: 0.9514

ASA_SCORE: 83.175

COIL: 0.8543

CONS_SCORE: 0.3387

DSS_SCORE: 0.5067

HELIX: 0.034

FCONS_SCORE: 0.9396

RIG_SCORE: 0.6555

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S167Y	TCGA-AA-3844	COAD	TCGA	VSDTPCVS	DEG_SCF_FBW7_1	0.7222
p.S167Y	DO9162	COAD	ICGC	VSDTPCVS	DEG_SCF_FBW7_1	0.7222
p.D179N	TCGA-BR-4184	STAD	TCGA	VSDTPCVS	DEG_SCF_FBW7_1	0.25
p.D179N	DO38328	STAD	ICGC	VSDTPCVS	DEG_SCF_FBW7_1	0.25
p.V175A	TCGA-BR-8680	STAD	TCGA	VSDTPCVS	DEG_SCF_FBW7_1	0.5825
p.V175A	DO47769	STAD	ICGC	VSDTPCVS	DEG_SCF_FBW7_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3T8	Zinc finger FYVE domain-containing protein 16	DEG_SCF_FBW7_1	169:176	VSDTPCVS	FBXW7	0.9514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons