DegronMD - Q7Z3T8(ZFYVE16)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P427S	TCGA-37-5819	LUSC	TCGA	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.P427S	DO26479	LUSC	ICGC	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.G424S	TCGA-58-8391	LUSC	TCGA	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2222
p.G424S	DO45440	LUSC	ICGC	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2222
p.S167Y	TCGA-AA-3844	COAD	TCGA	VSDTPCVS	DEG_SCF_FBW7_1	169:176	Mutation blocking phosphorylation signal	0.7222
p.S167Y	DO9162	COAD	ICGC	VSDTPCVS	DEG_SCF_FBW7_1	169:176	Mutation blocking phosphorylation signal	0.7222
p.L433I	TCGA-AN-A046	BRCA	TCGA	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.L433I	DO1285	BRCA	ICGC	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.S420R	TCGA-AP-A0LM	UCEC	TCGA	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1111
p.S420R	DO43306	UCEC	ICGC	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1111
p.D179N	TCGA-BR-4184	STAD	TCGA	VSDTPCVS	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.25
p.D179N	DO38328	STAD	ICGC	VSDTPCVS	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.25
p.V175A	TCGA-BR-8680	STAD	TCGA	VSDTPCVS	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.5825
p.V175A	DO47769	STAD	ICGC	VSDTPCVS	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.5825
p.F428L	TCGA-K4-AAQO	BLCA	TCGA	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.587
p.F428L	TCGA-S8-A6BW	ESCA	TCGA	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.587
p.F428L	DO219030	BLCA	ICGC	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.587
p.D432V	DO222608	BTCA	ICGC	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.6674
p.N431S	DO233270	GACA	ICGC	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.7069
p.S420I	DO229035	LICA	ICGC	FKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1111

Kaplan plot for ZFYVE16 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFYVE16

UniProt ID: Q7Z3T8

Entrez ID: 9765

Protein name: Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZFYVE16 in