DegronMD

Uniprot ID: Q7Z3T8

Source protein: Zinc finger FYVE domain-containing protein 16

Source gene: ZFYVE16

Class: DEG_APCC_KENBOX_2

Location: 428:432

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7147

ASA_SCORE: 96.08

COIL: 0.5608

CONS_SCORE: 0.3546

DSS_SCORE: 0.3289

HELIX: 0.4072

FCONS_SCORE: 1.0891

RIG_SCORE: 0.7998

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P427S	TCGA-37-5819	LUSC	TCGA	FKEND	DEG_APCC_KENBOX_2	0.3056
p.P427S	DO26479	LUSC	ICGC	FKEND	DEG_APCC_KENBOX_2	0.3056
p.G424S	TCGA-58-8391	LUSC	TCGA	FKEND	DEG_APCC_KENBOX_2	0.2222
p.G424S	DO45440	LUSC	ICGC	FKEND	DEG_APCC_KENBOX_2	0.2222
p.L433I	TCGA-AN-A046	BRCA	TCGA	FKEND	DEG_APCC_KENBOX_2	0.3056
p.L433I	DO1285	BRCA	ICGC	FKEND	DEG_APCC_KENBOX_2	0.3056
p.S420R	TCGA-AP-A0LM	UCEC	TCGA	FKEND	DEG_APCC_KENBOX_2	0.1111
p.S420R	DO43306	UCEC	ICGC	FKEND	DEG_APCC_KENBOX_2	0.1111
p.F428L	TCGA-K4-AAQO	BLCA	TCGA	FKEND	DEG_APCC_KENBOX_2	0.587
p.F428L	TCGA-S8-A6BW	ESCA	TCGA	FKEND	DEG_APCC_KENBOX_2	0.587
p.F428L	DO219030	BLCA	ICGC	FKEND	DEG_APCC_KENBOX_2	0.587
p.D432V	DO222608	BTCA	ICGC	FKEND	DEG_APCC_KENBOX_2	0.6674
p.N431S	DO233270	GACA	ICGC	FKEND	DEG_APCC_KENBOX_2	0.7069
p.S420I	DO229035	LICA	ICGC	FKEND	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60508	Pre-mRNA-processing factor 17	DEG_APCC_KENBOX_2	181:185	FKEND	APC,CDC20,FZR1	0.7085	More...
Q7Z3T8	Zinc finger FYVE domain-containing protein 16	DEG_APCC_KENBOX_2	428:432	FKEND	APC,CDC20,FZR1	0.7147	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons