DegronMD

Uniprot ID: O60508

Source protein: Pre-mRNA-processing factor 17

Source gene: CDC40

Class: DEG_APCC_KENBOX_2

Location: 181:185

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7085

ASA_SCORE: 87.68

COIL: 0.6876

CONS_SCORE: 0.4197

DSS_SCORE: 0.4769

HELIX: 0.1914

FCONS_SCORE: 0.9222

RIG_SCORE: 0.7693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D190H	TCGA-56-7731	LUSC	TCGA	FKEND	DEG_APCC_KENBOX_2	0.1944
p.D190H	DO45527	LUSC	ICGC	FKEND	DEG_APCC_KENBOX_2	0.1944
p.D185Y	TCGA-CN-4741	HNSC	TCGA	FKEND	DEG_APCC_KENBOX_2	0.6214
p.D185Y	DO14313	HNSC	ICGC	FKEND	DEG_APCC_KENBOX_2	0.6214
p.K180T	DO234363	ESAD	ICGC	FKEND	DEG_APCC_KENBOX_2	0.3056
p.D190Y	DO229029	LICA	ICGC	FKEND	DEG_APCC_KENBOX_2	0.1944
p.D190Y	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	FKEND	DEG_APCC_KENBOX_2	0.1944
p.D190Y	ACH-002272	Lymphoma	CCLE	FKEND	DEG_APCC_KENBOX_2	0.1944
p.D190Y	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	FKEND	DEG_APCC_KENBOX_2	0.1944
p.Q172R	DO50929	LICA	ICGC	FKEND	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60508	Pre-mRNA-processing factor 17	DEG_APCC_KENBOX_2	181:185	FKEND	APC,CDC20,FZR1	0.7085	More...
Q7Z3T8	Zinc finger FYVE domain-containing protein 16	DEG_APCC_KENBOX_2	428:432	FKEND	APC,CDC20,FZR1	0.7147	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons