DegronMD

Uniprot ID: Q9UHR4

Source protein: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Source gene: BAIAP2L1

Class: DEG_SCF_FBW7_1

Location: 254:261

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 74.55

COIL: 0.9413

CONS_SCORE: 0.406

DSS_SCORE: 0.6207

HELIX: 0.0231

FCONS_SCORE: 0.9994

RIG_SCORE: 0.6355

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E244K	TCGA-36-2547	OV	TCGA	VSGTPQAS	DEG_SCF_FBW7_1	0.0556
p.E244K	DO30990	OV	ICGC	VSGTPQAS	DEG_SCF_FBW7_1	0.0556
p.P253L	TCGA-ER-A194	SKCM	TCGA	VSGTPQAS	DEG_SCF_FBW7_1	0.3056
p.P253L	DO47646	SKCM	ICGC	VSGTPQAS	DEG_SCF_FBW7_1	0.3056
p.E245K	DO233155	GACA	ICGC	VSGTPQAS	DEG_SCF_FBW7_1	0.0833
p.V269M	SIDM01172	Acute Myeloid Leukemia	GDSC	VSGTPQAS	DEG_SCF_FBW7_1	0.1111
p.V269M	ACH-000146	Leukemia	CCLE	VSGTPQAS	DEG_SCF_FBW7_1	0.1111
p.V269M	THP-1	haematopoietic_and_lymphoid_tissue	COSMIC	VSGTPQAS	DEG_SCF_FBW7_1	0.1111
p.E265K	ACH-001608	Brain Cancer	CCLE	VSGTPQAS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	DEG_SCF_FBW7_1	254:261	VSGTPQAS	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons