DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 208:215

E3 ligase: FBXW7

DEGRON score: 0.8797

ASA_SCORE: 94.85

COIL: 0.8743

CONS_SCORE: 0

DSS_SCORE: 0.6095

HELIX: 0.0178

FCONS_SCORE: 0

RIG_SCORE: 0.6687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V208E	TCGA-94-A5I4	LUSC	TCGA	VSMTPAET	DEG_SCF_FBW7_1	0.7693
p.V208E	DO219175	LUSC	ICGC	VSMTPAET	DEG_SCF_FBW7_1	0.7693
p.P212Q	TCGA-AP-A1E0	UCEC	TCGA	VSMTPAET	DEG_SCF_FBW7_1	0.7035
p.P212Q	DO43154	UCEC	ICGC	VSMTPAET	DEG_SCF_FBW7_1	0.7035
p.G224R	TCGA-B5-A0JY	UCEC	TCGA	VSMTPAET	DEG_SCF_FBW7_1	0.0833
p.G224R	DO43041	UCEC	ICGC	VSMTPAET	DEG_SCF_FBW7_1	0.0833
p.D219N	TCGA-EE-A20C	SKCM	TCGA	VSMTPAET	DEG_SCF_FBW7_1	0.2222
p.D219N	DO222775	MELA	ICGC	VSMTPAET	DEG_SCF_FBW7_1	0.2222
p.D219N	DO47665	SKCM	ICGC	VSMTPAET	DEG_SCF_FBW7_1	0.2222
p.P223A	TCGA-GM-A3NW	BRCA	TCGA	VSMTPAET	DEG_SCF_FBW7_1	0.1111
p.P223A	DO3001	BRCA	ICGC	VSMTPAET	DEG_SCF_FBW7_1	0.1111
p.G224E	TCGA-YD-A9TB	SKCM	TCGA	VSMTPAET	DEG_SCF_FBW7_1	0.0833
p.G224E	DO23154	LINC	ICGC	VSMTPAET	DEG_SCF_FBW7_1	0.0833
p.G224E	DO45085	LINC	ICGC	VSMTPAET	DEG_SCF_FBW7_1	0.0833
p.G224E	DO51297	SKCM	ICGC	VSMTPAET	DEG_SCF_FBW7_1	0.0833
p.T211N	DO228940	LICA	ICGC	VSMTPAET	DEG_SCF_FBW7_1	0.8166
p.V217G	SIDM02071	Esophageal Carcinoma	GDSC	VSMTPAET	DEG_SCF_FBW7_1	0.2778
p.T222I	SIDM00783	Colorectal Carcinoma	GDSC	VSMTPAET	DEG_SCF_FBW7_1	0.5833
p.T222I	ACH-000971	Colon/Colorectal Cancer	CCLE	VSMTPAET	DEG_SCF_FBW7_1	0.5833
p.T222I	HCT-116	large_intestine	COSMIC	VSMTPAET	DEG_SCF_FBW7_1	0.5833
p.T215N	SIDM00720	Mesothelioma	GDSC	VSMTPAET	DEG_SCF_FBW7_1	0.7055
p.T215N	ACH-000648	Lung Cancer	CCLE	VSMTPAET	DEG_SCF_FBW7_1	0.7055
p.T215N	NCI-H28	pleura	COSMIC	VSMTPAET	DEG_SCF_FBW7_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	208:215	VSMTPAET	FBXW7	0.8797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons