DegronMD

Uniprot ID: Q9ULX3

Source protein: RNA-binding protein NOB1

Source gene: NOB1

Class: LIG_APCC_ABBA_1

Location: 370:375

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.804

ASA_SCORE: 36.5

COIL: 0.7755

CONS_SCORE: 0.3096

DSS_SCORE: 0.2894

HELIX: 0.1607

FCONS_SCORE: 0.8494

RIG_SCORE: 0.7845

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S380G	TCGA-BR-7707	STAD	TCGA	VSPFVE	LIG_APCC_ABBA_1	0.1944
p.S380G	DO38487	STAD	ICGC	VSPFVE	LIG_APCC_ABBA_1	0.1944
p.N360K	TCGA-D8-A1XK	BRCA	TCGA	VSPFVE	LIG_APCC_ABBA_1	0.0556
p.N360K	DO4749	BRCA	ICGC	VSPFVE	LIG_APCC_ABBA_1	0.0556
p.P364L	TCGA-FS-A1ZW	SKCM	TCGA	VSPFVE	LIG_APCC_ABBA_1	0.1667
p.P364L	DO37519	SKCM	ICGC	VSPFVE	LIG_APCC_ABBA_1	0.1667
p.R381C	TCGA-G4-6628	COAD	TCGA	VSPFVE	LIG_APCC_ABBA_1	0.1667
p.R381C	DO10132	COAD	ICGC	VSPFVE	LIG_APCC_ABBA_1	0.1667
p.P372L	TCGA-GJ-A6C0	LIHC	TCGA	VSPFVE	LIG_APCC_ABBA_1	0.6471
p.P372L	DO48486	LIHC	ICGC	VSPFVE	LIG_APCC_ABBA_1	0.6471
p.A368S	DO229024	LICA	ICGC	VSPFVE	LIG_APCC_ABBA_1	0.2778
p.N360S	SIDM00770	Small Cell Lung Carcinoma	GDSC	VSPFVE	LIG_APCC_ABBA_1	0.0556
p.N360S	ACH-000559	Lung Cancer	CCLE	VSPFVE	LIG_APCC_ABBA_1	0.0556
p.N360S	NCI-H1836	lung	COSMIC	VSPFVE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULX3	RNA-binding protein NOB1	LIG_APCC_ABBA_1	370:375	VSPFVE	APC,CDC20,FZR1	0.804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons