DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: LIG_APCC_ABBA_1

Location: 4020:4025

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6651

ASA_SCORE: 104.1833

COIL: 0.8637

CONS_SCORE: 0

DSS_SCORE: 0.4778

HELIX: 0.0213

FCONS_SCORE: 0

RIG_SCORE: 0.7432

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4030A	TCGA-86-8073	LUAD	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.1944
p.T4030A	DO23624	LUAD	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.1944
p.T4032A	TCGA-A5-A1OF	UCEC	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.1389
p.T4032A	DO42568	UCEC	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.1389
p.V4020A	TCGA-AZ-4315	COAD	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.6936
p.V4020A	DO8842	COAD	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.6936
p.D4019N	TCGA-BF-AAOU	SKCM	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.3056
p.D4019N	DO219460	SKCM	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.3056
p.D4025N	TCGA-BH-A18P	BRCA	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.6932
p.D4025N	DO3346	BRCA	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.6932
p.R4018K	TCGA-D1-A103	UCEC	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.2778
p.R4018K	DO42312	UCEC	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.2778
p.S4033I	TCGA-E9-A244	BRCA	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.1111
p.S4033I	DO5263	BRCA	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.1111
p.D4025V	TCGA-EB-A3Y7	SKCM	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.7785
p.D4025V	DO37499	SKCM	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.7785
p.S4011F	TCGA-EE-A2M6	SKCM	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.S4011F	TCGA-EE-A3AG	SKCM	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.S4011F	TCGA-FS-A1ZT	SKCM	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.S4011F	TCGA-GN-A266	SKCM	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.S4011F	DO220911	MELA	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.S4011F	DO222514	MELA	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.S4011F	DO37471	SKCM	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.S4011F	DO37468	SKCM	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.S4011F	DO37432	SKCM	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.S4011F	DO37976	SKCM	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.M4024I	TCGA-EE-A2MF	SKCM	TCGA	VSPYMD	LIG_APCC_ABBA_1	0.6507
p.M4024I	DO222491	MELA	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.6507
p.M4024I	DO51249	SKCM	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.6507
p.I4034F	DO230334	COCA	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.I4034F	DO229013	COCA	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.I4034F	DO229480	LAML	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.I4034F	DO229505	LAML	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.I4034F	DO228941	LICA	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.I4034F	DO231049	LUSC	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.0833
p.D4019E	DO229031	LICA	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.3056
p.T4032K	DO229035	LICA	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.1389
p.L4017M	DO229045	LICA	ICGC	VSPYMD	LIG_APCC_ABBA_1	0.25
p.F4012L	SIDM01043	Other Sarcomas	GDSC	VSPYMD	LIG_APCC_ABBA_1	0.1111
p.F4012L	ACH-000913	Endometrial/Uterine Cancer	CCLE	VSPYMD	LIG_APCC_ABBA_1	0.1111
p.F4012L	ESS-1	endometrium	COSMIC	VSPYMD	LIG_APCC_ABBA_1	0.1111
p.S4027R	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	VSPYMD	LIG_APCC_ABBA_1	0.2778
p.S4027R	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	VSPYMD	LIG_APCC_ABBA_1	0.2778
p.S4027R	SIDM01432	Kidney Carcinoma	GDSC	VSPYMD	LIG_APCC_ABBA_1	0.2778
p.S4027R	SIDM00500	Colorectal Carcinoma	GDSC	VSPYMD	LIG_APCC_ABBA_1	0.2778
p.T4030I	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	VSPYMD	LIG_APCC_ABBA_1	0.1944
p.T4030I	ACH-000886	Lung Cancer	CCLE	VSPYMD	LIG_APCC_ABBA_1	0.1944
p.T4030I	NCI-H2009	lung	COSMIC	VSPYMD	LIG_APCC_ABBA_1	0.1944
p.S4021N	SIDM00118	Colorectal Carcinoma	GDSC	VSPYMD	LIG_APCC_ABBA_1	0.5958
p.S4021N	ACH-001081	Colon/Colorectal Cancer	CCLE	VSPYMD	LIG_APCC_ABBA_1	0.5958
p.S4021N	HCC2998	large_intestine	COSMIC	VSPYMD	LIG_APCC_ABBA_1	0.5958
p.S4021R	SIDM01335	Kidney Carcinoma	GDSC	VSPYMD	LIG_APCC_ABBA_1	0.6316
p.S4021R	ACH-000513	Kidney Cancer	CCLE	VSPYMD	LIG_APCC_ABBA_1	0.6316
p.V4020I	ACH-000606	Head and Neck Cancer	CCLE	VSPYMD	LIG_APCC_ABBA_1	0.5965

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSPYMD

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VSPYMD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	LIG_APCC_ABBA_1	4020:4025	VSPYMD	APC,CDC20,FZR1	0.6651	More...