DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 5276:5283

E3 ligase: FBXW7

DEGRON score: 0.8751

ASA_SCORE: 85.9875

COIL: 0.9603

CONS_SCORE: 0.344

DSS_SCORE: 0.5116

HELIX: 0.0186

FCONS_SCORE: 0.8072

RIG_SCORE: 0.5878

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T5286P	DO224668	COCA	ICGC	VSSTPTPT	DEG_SCF_FBW7_1	0.25
p.T5286P	DO223150	ESCA	ICGC	VSSTPTPT	DEG_SCF_FBW7_1	0.25
p.T5286P	DO22382	LGG	ICGC	VSSTPTPT	DEG_SCF_FBW7_1	0.25
p.L5293P	DO224744	COCA	ICGC	VSSTPTPT	DEG_SCF_FBW7_1	0.0556
p.P5292L	DO231176	LUSC	ICGC	VSSTPTPT	DEG_SCF_FBW7_1	0.0833
p.T5284P	DO228469	MALY	ICGC	VSSTPTPT	DEG_SCF_FBW7_1	0.3056
p.T5284P	DO229229	THCA	ICGC	VSSTPTPT	DEG_SCF_FBW7_1	0.3056
p.T5284P	DO229232	THCA	ICGC	VSSTPTPT	DEG_SCF_FBW7_1	0.3056
p.A5276S	DO232061	ORCA	ICGC	VSSTPTPT	DEG_SCF_FBW7_1	0.7588
p.T5266R	SIDM00720	Mesothelioma	GDSC	VSSTPTPT	DEG_SCF_FBW7_1	0.0556
p.A5270T	ACH-001280	Sarcoma	CCLE	VSSTPTPT	DEG_SCF_FBW7_1	0.1667
p.T5283P	ACH-001957	Bone Cancer	CCLE	VSSTPTPT	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	5276:5283	VSSTPTPT	FBXW7	0.8751	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons