DegronMD

Uniprot ID: P49792

Source protein: E3 SUMO-protein ligase RanBP2

Source gene: RANBP2

Class: DEG_SCF_FBW7_1

Location: 1642:1648

E3 ligase: FBXW7

DEGRON score: 0.9375

ASA_SCORE: 76.1143

COIL: 0.8561

CONS_SCORE: 0.3909

DSS_SCORE: 0.5803

HELIX: 0.0564

FCONS_SCORE: 1.2383

RIG_SCORE: 0.6316

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1632L	TCGA-EE-A17X	SKCM	TCGA	VSTPASS	DEG_SCF_FBW7_1	0.0556
p.P1632L	DO37931	SKCM	ICGC	VSTPASS	DEG_SCF_FBW7_1	0.0556
p.G1633C	DO229041	LICA	ICGC	VSTPASS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SCF_FBW7_1	1642:1648	VSTPASS	FBXW7	0.9375	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons