DegronMD

Uniprot ID: Q2KHR3

Source protein: Glutamine and serine-rich protein 1

Source gene: QSER1

Class: DEG_SCF_FBW7_1

Location: 1246:1252

E3 ligase: FBXW7

DEGRON score: 0.9786

ASA_SCORE: 87.0429

COIL: 0.8969

CONS_SCORE: 0.641

DSS_SCORE: 0.4631

HELIX: 0.0386

FCONS_SCORE: 0.9958

RIG_SCORE: 0.7208

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1245R	TCGA-85-7710	LUSC	TCGA	VSTPLTT	DEG_SCF_FBW7_1	0.3056
p.S1245R	DO26826	LUSC	ICGC	VSTPLTT	DEG_SCF_FBW7_1	0.3056
p.T1248A	DO225346	BRCA	ICGC	VSTPLTT	DEG_SCF_FBW7_1	0.825
p.S1257Y	SIDM00216	Colorectal Carcinoma	GDSC	VSTPLTT	DEG_SCF_FBW7_1	0.6389
p.S1257Y	ACH-000989	Colon/Colorectal Cancer	CCLE	VSTPLTT	DEG_SCF_FBW7_1	0.6389
p.S1257Y	SNU-175	large_intestine	COSMIC	VSTPLTT	DEG_SCF_FBW7_1	0.6389
p.T1239A	NCI-H211	lung	COSMIC	VSTPLTT	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SCF_FBW7_1	1246:1252	VSTPLTT	FBXW7	0.9786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons