DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 3961:3967

E3 ligase: FBXW7

DEGRON score: 0.6636

ASA_SCORE: 88.4286

COIL: 0.8346

CONS_SCORE: 0.5236

DSS_SCORE: 0.464

HELIX: 0.0104

FCONS_SCORE: 0.896

RIG_SCORE: 0.781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3956E	TCGA-39-5030	LUSC	TCGA	VSTPVIT	DEG_SCF_FBW7_1	0.1944
p.A3956E	DO7418	CLLE	ICGC	VSTPVIT	DEG_SCF_FBW7_1	0.1944
p.A3956E	DO27176	LUSC	ICGC	VSTPVIT	DEG_SCF_FBW7_1	0.1944
p.I3966M	TCGA-78-7147	LUAD	TCGA	VSTPVIT	DEG_SCF_FBW7_1	0.6507
p.I3966M	DO24527	LUAD	ICGC	VSTPVIT	DEG_SCF_FBW7_1	0.6507
p.T3957I	TCGA-AA-A01I	COAD	TCGA	VSTPVIT	DEG_SCF_FBW7_1	0.2222
p.T3957I	DO10510	COAD	ICGC	VSTPVIT	DEG_SCF_FBW7_1	0.2222
p.T3967A	TCGA-EE-A20C	SKCM	TCGA	VSTPVIT	DEG_SCF_FBW7_1	0.7139
p.T3967A	DO222775	MELA	ICGC	VSTPVIT	DEG_SCF_FBW7_1	0.7139
p.T3967A	DO47665	SKCM	ICGC	VSTPVIT	DEG_SCF_FBW7_1	0.7139
p.V3965L	DO233828	GACA	ICGC	VSTPVIT	DEG_SCF_FBW7_1	0.5654
p.D3952Y	DO229027	LICA	ICGC	VSTPVIT	DEG_SCF_FBW7_1	0.0833
p.E3970K	DO222494	MELA	ICGC	VSTPVIT	DEG_SCF_FBW7_1	0.25
p.G3959A	SIDM01449	Pancreatic Carcinoma	GDSC	VSTPVIT	DEG_SCF_FBW7_1	0.2778
p.G3959A	ACH-000517	Pancreatic Cancer	CCLE	VSTPVIT	DEG_SCF_FBW7_1	0.2778
p.A3951V	ACH-001786	Colon/Colorectal Cancer	CCLE	VSTPVIT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3961:3967	VSTPVIT	FBXW7	0.6636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons