DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 1756:1763

E3 ligase: FBXW7

DEGRON score: 0.6185

ASA_SCORE: 88.8125

COIL: 0.8835

CONS_SCORE: 0.5341

DSS_SCORE: 0.5761

HELIX: 0.0176

FCONS_SCORE: 0.9028

RIG_SCORE: 0.7221

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1760Q	TCGA-05-5420	LUAD	TCGA	VSTTPVLS	DEG_SCF_FBW7_1	0.7035
p.P1760Q	DO26005	LUAD	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.7035
p.T1759M	TCGA-17-Z055	LUAD	TCGA	VSTTPVLS	DEG_SCF_FBW7_1	0.7423
p.T1759M	TCGA-HT-7687	LGG	TCGA	VSTTPVLS	DEG_SCF_FBW7_1	0.7423
p.T1759M	DO22151	LGG	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.7423
p.P1760S	TCGA-2W-A8YY	CESC	TCGA	VSTTPVLS	DEG_SCF_FBW7_1	0.6752
p.P1760S	DO223732	CESC	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.6752
p.P1760S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VSTTPVLS	DEG_SCF_FBW7_1	0.6752
p.P1760S	ACH-000891	Lung Cancer	CCLE	VSTTPVLS	DEG_SCF_FBW7_1	0.6752
p.L1762H	TCGA-3P-A9WA	OV	TCGA	VSTTPVLS	DEG_SCF_FBW7_1	0.6202
p.L1762H	DO50655	OV	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.6202
p.P1760L	TCGA-D7-A4YV	STAD	TCGA	VSTTPVLS	DEG_SCF_FBW7_1	0.7582
p.P1760L	DO47777	STAD	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.7582
p.G1747E	TCGA-EE-A3AG	SKCM	TCGA	VSTTPVLS	DEG_SCF_FBW7_1	0.0833
p.G1747E	DO37471	SKCM	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.0833
p.V1761I	TCGA-G4-6586	COAD	TCGA	VSTTPVLS	DEG_SCF_FBW7_1	0.5965
p.V1761I	DO9698	COAD	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.5965
p.E1765D	TCGA-HT-8106	LGG	TCGA	VSTTPVLS	DEG_SCF_FBW7_1	0.2778
p.E1765D	DO22711	LGG	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.2778
p.E1765K	TCGA-PJ-A8JU	KIRP	TCGA	VSTTPVLS	DEG_SCF_FBW7_1	0.2778
p.E1765K	DO48523	KIRP	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.2778
p.T1748I	DO225007	BRCA	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.1111
p.S1757G	DO50452	ESAD	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.5882
p.I1754M	DO228950	LICA	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.2778
p.I1754M	DO229030	LICA	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.2778
p.T1748S	DO228960	LICA	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.1111
p.T1749P	DO228584	MALY	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.1389
p.L1762V	DO218868	SKCA	ICGC	VSTTPVLS	DEG_SCF_FBW7_1	0.5654
p.S1753R	SIDM01126	Small Cell Lung Carcinoma	GDSC	VSTTPVLS	DEG_SCF_FBW7_1	0.25
p.S1753R	ACH-001599	Lung Cancer	CCLE	VSTTPVLS	DEG_SCF_FBW7_1	0.25
p.S1753R	NCI-H64	lung	COSMIC	VSTTPVLS	DEG_SCF_FBW7_1	0.25
p.S1767N	SIDM00963	Breast Carcinoma	GDSC	VSTTPVLS	DEG_SCF_FBW7_1	0.2222
p.S1767I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VSTTPVLS	DEG_SCF_FBW7_1	0.2222
p.S1767I	ACH-000672	Lung Cancer	CCLE	VSTTPVLS	DEG_SCF_FBW7_1	0.2222
p.S1767I	IA-LM	lung	COSMIC	VSTTPVLS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTTPVLS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of VSTTPVLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1756:1763	VSTTPVLS	FBXW7	0.6185	More...