DegronMD

Uniprot ID: Q6IPR3

Source protein: tRNA wybutosine-synthesizing protein 3 homolog

Source gene: TYW3

Class: LIG_APCC_ABBA_1

Location: 252:257

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5451

ASA_SCORE: 54.7

COIL: 0.4922

CONS_SCORE: 0.4233

DSS_SCORE: 0.7458

HELIX: 0.061

FCONS_SCORE: 1.0379

RIG_SCORE: 0.8407

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D244V	TCGA-64-5781	LUAD	TCGA	VTIFPE	LIG_APCC_ABBA_1	0.1111
p.F255I	TCGA-86-8673	LUAD	TCGA	VTIFPE	LIG_APCC_ABBA_1	0.7415
p.D247Y	TCGA-98-8021	LUSC	TCGA	VTIFPE	LIG_APCC_ABBA_1	0.1944
p.Y259D	TCGA-BR-8680	STAD	TCGA	VTIFPE	LIG_APCC_ABBA_1	0.2778
p.D258N	SIDM00587	Biliary Tract Carcinoma	GDSC	VTIFPE	LIG_APCC_ABBA_1	0.3056
p.D258N	SIDM00500	Colorectal Carcinoma	GDSC	VTIFPE	LIG_APCC_ABBA_1	0.3056
p.D258N	HuCCT1	biliary_tract	COSMIC	VTIFPE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6IPR3	tRNA wybutosine-synthesizing protein 3 homolog	LIG_APCC_ABBA_1	252:257	VTIFPE	APC,CDC20,FZR1	0.5451	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons