DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VTPEIT
Uniprot ID:
C9J069
Source protein:
Apical junction component 1 homolog
Source gene:
AJM1
Class:
DEG_SCF_FBW7_1
Location:
529:534
E3 ligase:
FBXW7
DEGRON score:
0.7555
ASA_SCORE:
71.8
COIL:
0.7282
CONS_SCORE:
0.7133
DSS_SCORE:
0.4027
HELIX:
0.0148
FCONS_SCORE:
1.0662
RIG_SCORE:
0.8612
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with AJM1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTPEIT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
C9J069
Apical junction component 1 homolog
DEG_SCF_FBW7_1
529:534
VTPEIT
FBXW7
0.7555
More...