DegronMD

Uniprot ID: Q4G176

Source protein: Malonate--CoA ligase ACSF3, mitochondrial

Source gene: ACSF3

Class: DEG_SCF_FBW7_2

Location: 414:419

E3 ligase: FBXW7

DEGRON score: 0.8152

ASA_SCORE: 69.2333

COIL: 0.8727

CONS_SCORE: 0.2806

DSS_SCORE: 0.5695

HELIX: 0.026

FCONS_SCORE: 0.7462

RIG_SCORE: 0.7183

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D408Y	TCGA-50-5930	LUAD	TCGA	VTPGFE	DEG_SCF_FBW7_2	0.1667
p.D408Y	DO25189	LUAD	ICGC	VTPGFE	DEG_SCF_FBW7_2	0.1667
p.F418L	TCGA-AB-2913	LAML	TCGA	VTPGFE	DEG_SCF_FBW7_2	0.587
p.F418L	DO21493	LAML	ICGC	VTPGFE	DEG_SCF_FBW7_2	0.587
p.E409K	TCGA-EE-A3AE	SKCM	TCGA	VTPGFE	DEG_SCF_FBW7_2	0.1944
p.E409K	DO37802	SKCM	ICGC	VTPGFE	DEG_SCF_FBW7_2	0.1944
p.P416S	DO222526	ESCA	ICGC	VTPGFE	DEG_SCF_FBW7_2	0.6752
p.R428M	DO46342	OV	ICGC	VTPGFE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4G176	Malonate--CoA ligase ACSF3, mitochondrial	DEG_SCF_FBW7_2	414:419	VTPGFE	FBXW7	0.8152	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons