DegronMD

Uniprot ID: Q9Y4B5

Source protein: Microtubule cross-linking factor 1

Source gene: MTCL1

Class: DEG_SCF_FBW7_1

Location: 1416:1421

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 55.1833

COIL: 0.95

CONS_SCORE: 0.4568

DSS_SCORE: 0.583

HELIX: 0.0135

FCONS_SCORE: 0.9827

RIG_SCORE: 0.6803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1413R	SIDM01175	Other Sarcomas	GDSC	VTPPLS	DEG_SCF_FBW7_1	0.3611
p.G1413R	SW684	soft_tissue	COSMIC	VTPPLS	DEG_SCF_FBW7_1	0.3611
p.S1427A	SIDM00290	Gastric Carcinoma	GDSC	VTPPLS	DEG_SCF_FBW7_1	0.6111
p.S1427A	HGC-27	stomach	COSMIC	VTPPLS	DEG_SCF_FBW7_1	0.6111
p.R1428W	HGC-27	stomach	COSMIC	VTPPLS	DEG_SCF_FBW7_1	0.1389
p.K1426R	U031	kidney	COSMIC	VTPPLS	DEG_SCF_FBW7_1	0.3056
p.R1424Q	IGROV-1	ovary	COSMIC	VTPPLS	DEG_SCF_FBW7_1	0.25
p.G1426D	Mewo	skin	COSMIC	VTPPLS	DEG_SCF_FBW7_1	0.3056
p.R1428Q	TK	haematopoietic_and_lymphoid_tissue	COSMIC	VTPPLS	DEG_SCF_FBW7_1	0.1389
p.D1417G	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	VTPPLS	DEG_SCF_FBW7_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4B5	Microtubule cross-linking factor 1	DEG_SCF_FBW7_1	1416:1421	VTPPLS	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons