DegronMD

Uniprot ID: Q9BQI9

Source protein: Nuclear receptor-interacting protein 2

Source gene: NRIP2

Class: DEG_SCF_FBW7_1

Location: 35:40

E3 ligase: FBXW7

DEGRON score: 0.9624

ASA_SCORE: 88.5167

COIL: 0.9685

CONS_SCORE: 0.3644

DSS_SCORE: 0.8054

HELIX: 0.007

FCONS_SCORE: 1.0903

RIG_SCORE: 0.5115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E32Q	TCGA-24-2290	OV	TCGA	VTPPPS	DEG_SCF_FBW7_1	0.25
p.E32Q	DO30090	OV	ICGC	VTPPPS	DEG_SCF_FBW7_1	0.25
p.E32Q	SIDM00632	Non-Cancerous	GDSC	VTPPPS	DEG_SCF_FBW7_1	0.25
p.E32Q	ACH-002247	Non-Cancerous	CCLE	VTPPPS	DEG_SCF_FBW7_1	0.25
p.E32Q	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	VTPPPS	DEG_SCF_FBW7_1	0.25
p.P37L	TCGA-BT-A3PJ	BLCA	TCGA	VTPPPS	DEG_SCF_FBW7_1	0.7582
p.P37L	DO44097	BLCA	ICGC	VTPPPS	DEG_SCF_FBW7_1	0.7582
p.G28E	TCGA-EE-A3JD	SKCM	TCGA	VTPPPS	DEG_SCF_FBW7_1	0.1389
p.G28E	DO50299	SKCM	ICGC	VTPPPS	DEG_SCF_FBW7_1	0.1389
p.P47T	TCGA-F7-A61V	HNSC	TCGA	VTPPPS	DEG_SCF_FBW7_1	0.1389
p.P47T	DO44437	HNSC	ICGC	VTPPPS	DEG_SCF_FBW7_1	0.1389
p.P44H	DO222794	COCA	ICGC	VTPPPS	DEG_SCF_FBW7_1	0.2222
p.Q26K	DO233158	GACA	ICGC	VTPPPS	DEG_SCF_FBW7_1	0.0833
p.Q26K	DO229025	LICA	ICGC	VTPPPS	DEG_SCF_FBW7_1	0.0833
p.S34P	DO233792	GACA	ICGC	VTPPPS	DEG_SCF_FBW7_1	0.3056
p.A48E	DO229063	LICA	ICGC	VTPPPS	DEG_SCF_FBW7_1	0.1111
p.P47S	DO50970	LICA	ICGC	VTPPPS	DEG_SCF_FBW7_1	0.1389
p.P38S	ACH-002024	Colon/Colorectal Cancer	CCLE	VTPPPS	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQI9	Nuclear receptor-interacting protein 2	DEG_SCF_FBW7_1	35:40	VTPPPS	FBXW7	0.9624	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons