DegronMD

Uniprot ID: A1L167

Source protein: Ubiquitin-conjugating enzyme E2Q-like protein 1

Source gene: UBE2QL1

Class: DEG_SCF_FBW7_1

Location: 154:159

E3 ligase: FBXW7

DEGRON score: 0.9837

ASA_SCORE: 78.3667

COIL: 0.8623

CONS_SCORE: 0.6647

DSS_SCORE: 0.7169

HELIX: 0.0907

FCONS_SCORE: 1.0687

RIG_SCORE: 0.7451

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D160N	TCGA-AA-A00N	COAD	TCGA	VTPPVS	DEG_SCF_FBW7_1	0.3056
p.D160N	DO9876	COAD	ICGC	VTPPVS	DEG_SCF_FBW7_1	0.3056
p.T147M	TCGA-AP-A059	UCEC	TCGA	VTPPVS	DEG_SCF_FBW7_1	0.1389
p.T147M	DO41361	UCEC	ICGC	VTPPVS	DEG_SCF_FBW7_1	0.1389
p.T147M	SIDM00118	Colorectal Carcinoma	GDSC	VTPPVS	DEG_SCF_FBW7_1	0.1389
p.T147M	ACH-001081	Colon/Colorectal Cancer	CCLE	VTPPVS	DEG_SCF_FBW7_1	0.1389
p.T147M	HCC2998	large_intestine	COSMIC	VTPPVS	DEG_SCF_FBW7_1	0.1389
p.V145M	TCGA-B5-A11Y	UCEC	TCGA	VTPPVS	DEG_SCF_FBW7_1	0.0833
p.V145M	DO40889	UCEC	ICGC	VTPPVS	DEG_SCF_FBW7_1	0.0833
p.L144F	DO229018	LICA	ICGC	VTPPVS	DEG_SCF_FBW7_1	0.0556
p.G152S	DO37607	SKCM	ICGC	VTPPVS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L167	Ubiquitin-conjugating enzyme E2Q-like protein 1	DEG_SCF_FBW7_1	154:159	VTPPVS	FBXW7	0.9837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons