DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SCF_FBW7_1

Location: 1278:1283

E3 ligase: FBXW7

DEGRON score: 0.9813

ASA_SCORE: 85.7667

COIL: 0.7777

CONS_SCORE: 0.3739

DSS_SCORE: 0.7803

HELIX: 0.02

FCONS_SCORE: 1.1385

RIG_SCORE: 0.6571

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1272T	TCGA-17-Z056	LUAD	TCGA	VTPQAT	DEG_SCF_FBW7_1	0.1667
p.V1278I	TCGA-85-8351	LUSC	TCGA	VTPQAT	DEG_SCF_FBW7_1	0.5965
p.V1278I	TCGA-BR-8361	STAD	TCGA	VTPQAT	DEG_SCF_FBW7_1	0.5965
p.V1278I	DO45447	LUSC	ICGC	VTPQAT	DEG_SCF_FBW7_1	0.5965
p.V1278I	DO48032	STAD	ICGC	VTPQAT	DEG_SCF_FBW7_1	0.5965
p.A1277T	TCGA-D3-A2JL	SKCM	TCGA	VTPQAT	DEG_SCF_FBW7_1	0.3056
p.A1277T	DO47278	SKCM	ICGC	VTPQAT	DEG_SCF_FBW7_1	0.3056
p.A1290D	TCGA-F4-6703	COAD	TCGA	VTPQAT	DEG_SCF_FBW7_1	0.1389
p.A1290D	DO9908	COAD	ICGC	VTPQAT	DEG_SCF_FBW7_1	0.1389
p.T1276M	TCGA-VQ-A91D	STAD	TCGA	VTPQAT	DEG_SCF_FBW7_1	0.7222
p.T1276M	DO51783	STAD	ICGC	VTPQAT	DEG_SCF_FBW7_1	0.7222
p.T1276M	SIDM00458	Acute Myeloid Leukemia	GDSC	VTPQAT	DEG_SCF_FBW7_1	0.7222
p.T1276M	ACH-000751	Leukemia	CCLE	VTPQAT	DEG_SCF_FBW7_1	0.7222
p.T1276M	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	VTPQAT	DEG_SCF_FBW7_1	0.7222
p.S1268L	DO222543	COCA	ICGC	VTPQAT	DEG_SCF_FBW7_1	0.0556
p.G1269R	DO220882	MELA	ICGC	VTPQAT	DEG_SCF_FBW7_1	0.0833
p.P1272R	SIDM00878	Breast Carcinoma	GDSC	VTPQAT	DEG_SCF_FBW7_1	0.1667
p.P1272R	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VTPQAT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	1278:1283	VTPQAT	FBXW7	0.9813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons