DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VTPRST
Uniprot ID:
Q2TAK8
Source protein:
PWWP domain-containing DNA repair factor 3A
Source gene:
PWWP3A
Class:
DEG_SCF_FBW7_1
Location:
337:342
E3 ligase:
FBXW7
DEGRON score:
0.8934
ASA_SCORE:
92.75
COIL:
0.897
CONS_SCORE:
0.3554
DSS_SCORE:
0.8191
HELIX:
0.0798
FCONS_SCORE:
1.0472
RIG_SCORE:
0.6026
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PWWP3A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTPRST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2TAK8
PWWP domain-containing DNA repair factor 3A
DEG_SCF_FBW7_1
337:342
VTPRST
FBXW7
0.8934
More...