DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VTPRTT
Uniprot ID:
Q8IZF6
Source protein:
Adhesion G-protein coupled receptor G4
Source gene:
ADGRG4
Class:
DEG_SCF_FBW7_1
Location:
1595:1600
E3 ligase:
FBXW7
DEGRON score:
0.9642
ASA_SCORE:
100.3167
COIL:
0.9202
CONS_SCORE:
0.7383
DSS_SCORE:
0.3474
HELIX:
0.0167
FCONS_SCORE:
0.981
RIG_SCORE:
0.7815
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ADGRG4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTPRTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IZF6
Adhesion G-protein coupled receptor G4
DEG_SCF_FBW7_1
1595:1600
VTPRTT
FBXW7
0.9642
More...