DegronMD

Uniprot ID: Q9ULG6

Source protein: Cell cycle progression protein 1

Source gene: CCPG1

Class: DEG_SCF_FBW7_1

Location: 30:35

E3 ligase: FBXW7

DEGRON score: 0.5963

ASA_SCORE: 85.5167

COIL: 0.8908

CONS_SCORE: 0.3732

DSS_SCORE: 0.613

HELIX: 0.0628

FCONS_SCORE: 0.7401

RIG_SCORE: 0.6957

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A39T	TCGA-77-7337	LUSC	TCGA	VTPTDS	DEG_SCF_FBW7_1	0.2222
p.A39T	DO27445	LUSC	ICGC	VTPTDS	DEG_SCF_FBW7_1	0.2222
p.A39T	SIDM00680	Colorectal Carcinoma	GDSC	VTPTDS	DEG_SCF_FBW7_1	0.2222
p.A39T	LS-180	large_intestine	COSMIC	VTPTDS	DEG_SCF_FBW7_1	0.2222
p.S35N	TCGA-A5-A0G1	UCEC	TCGA	VTPTDS	DEG_SCF_FBW7_1	0.7069
p.S35N	DO42472	UCEC	ICGC	VTPTDS	DEG_SCF_FBW7_1	0.7069
p.E41K	TCGA-C5-A7CL	CESC	TCGA	VTPTDS	DEG_SCF_FBW7_1	0.1667
p.E41K	DO49887	CESC	ICGC	VTPTDS	DEG_SCF_FBW7_1	0.1667
p.T31S	TCGA-E9-A24A	BRCA	TCGA	VTPTDS	DEG_SCF_FBW7_1	0.7116
p.T31S	DO4861	BRCA	ICGC	VTPTDS	DEG_SCF_FBW7_1	0.7116
p.G21W	TCGA-GN-A26C	SKCM	TCGA	VTPTDS	DEG_SCF_FBW7_1	0.0833
p.G21W	DO37782	SKCM	ICGC	VTPTDS	DEG_SCF_FBW7_1	0.0833
p.S35C	TCGA-MN-A4N4	LUAD	TCGA	VTPTDS	DEG_SCF_FBW7_1	0.7541
p.S35C	DO26250	LUAD	ICGC	VTPTDS	DEG_SCF_FBW7_1	0.7541
p.M26K	SIDM01619	Endometrial Carcinoma	GDSC	VTPTDS	DEG_SCF_FBW7_1	0.2222
p.M26K	ACH-000984	Endometrial/Uterine Cancer	CCLE	VTPTDS	DEG_SCF_FBW7_1	0.2222
p.S22P	ACH-000999	Colon/Colorectal Cancer	CCLE	VTPTDS	DEG_SCF_FBW7_1	0.1111
p.S22P	SNU-1040	large_intestine	COSMIC	VTPTDS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULG6	Cell cycle progression protein 1	DEG_SCF_FBW7_1	30:35	VTPTDS	FBXW7	0.5963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons