DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 10181:10186

E3 ligase: FBXW7

DEGRON score: 0.9428

ASA_SCORE: 96.75

COIL: 0.9382

CONS_SCORE: 0

DSS_SCORE: 0.6423

HELIX: 0.0088

FCONS_SCORE: 0

RIG_SCORE: 0.6226

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P10190H	TCGA-05-4382	LUAD	TCGA	VTPTNT	DEG_SCF_FBW7_1	0.2222
p.P10190H	DO24900	LUAD	ICGC	VTPTNT	DEG_SCF_FBW7_1	0.2222
p.K10171E	TCGA-A6-6648	COAD	TCGA	VTPTNT	DEG_SCF_FBW7_1	0.1667
p.K10171E	DO10196	COAD	ICGC	VTPTNT	DEG_SCF_FBW7_1	0.1667
p.T10186I	TCGA-AP-A051	UCEC	TCGA	VTPTNT	DEG_SCF_FBW7_1	0.7078
p.T10186I	DO42673	UCEC	ICGC	VTPTNT	DEG_SCF_FBW7_1	0.7078
p.T10182I	TCGA-BR-4361	STAD	TCGA	VTPTNT	DEG_SCF_FBW7_1	0.7078
p.T10182I	DO38887	STAD	ICGC	VTPTNT	DEG_SCF_FBW7_1	0.7078
p.M10174V	TCGA-CG-4306	STAD	TCGA	VTPTNT	DEG_SCF_FBW7_1	0.1389
p.M10174V	DO38567	STAD	ICGC	VTPTNT	DEG_SCF_FBW7_1	0.1389
p.S10188F	TCGA-D3-A2JO	SKCM	TCGA	VTPTNT	DEG_SCF_FBW7_1	0.2778
p.S10188F	DO47619	SKCM	ICGC	VTPTNT	DEG_SCF_FBW7_1	0.2778
p.P10190S	TCGA-D3-A3C7	SKCM	TCGA	VTPTNT	DEG_SCF_FBW7_1	0.2222
p.P10190S	TCGA-DA-A95Y	SKCM	TCGA	VTPTNT	DEG_SCF_FBW7_1	0.2222
p.P10190S	DO47569	SKCM	ICGC	VTPTNT	DEG_SCF_FBW7_1	0.2222
p.P10190S	DO223908	SKCM	ICGC	VTPTNT	DEG_SCF_FBW7_1	0.2222
p.N10173K	DO229031	LICA	ICGC	VTPTNT	DEG_SCF_FBW7_1	0.1111
p.S10189F	DO222527	MELA	ICGC	VTPTNT	DEG_SCF_FBW7_1	0.25
p.K10171R	SIDM00705	Non-Cancerous	GDSC	VTPTNT	DEG_SCF_FBW7_1	0.1667
p.K10171R	SIDM00706	Small Cell Lung Carcinoma	GDSC	VTPTNT	DEG_SCF_FBW7_1	0.1667
p.K10171R	ACH-000290	Lung Cancer	CCLE	VTPTNT	DEG_SCF_FBW7_1	0.1667
p.K10171R	ACH-002369	Non-Cancerous	CCLE	VTPTNT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	10181:10186	VTPTNT	FBXW7	0.9428	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons