DegronMD

Uniprot ID: Q6KB66

Source protein: Keratin, type II cytoskeletal 80

Source gene: KRT80

Class: DEG_SCF_FBW7_1

Location: 18:23

E3 ligase: FBXW7

DEGRON score: 0.9232

ASA_SCORE: 67.9667

COIL: 0.826

CONS_SCORE: 0.5864

DSS_SCORE: 0.3678

HELIX: 0.014

FCONS_SCORE: 1.4879

RIG_SCORE: 0.6764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P20S	TCGA-FR-A726	SKCM	TCGA	VTPVGS	DEG_SCF_FBW7_1	0.6752
p.P20S	DO48665	SKCM	ICGC	VTPVGS	DEG_SCF_FBW7_1	0.6752
p.S29L	TCGA-S5-AA26	BLCA	TCGA	VTPVGS	DEG_SCF_FBW7_1	0.6111
p.S29L	DO51904	BLCA	ICGC	VTPVGS	DEG_SCF_FBW7_1	0.6111
p.S29L	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	VTPVGS	DEG_SCF_FBW7_1	0.6111
p.S29L	ACH-000528	Lung Cancer	CCLE	VTPVGS	DEG_SCF_FBW7_1	0.6111
p.S29L	ABC-1	lung	COSMIC	VTPVGS	DEG_SCF_FBW7_1	0.6111
p.R25Q	DO227979	COCA	ICGC	VTPVGS	DEG_SCF_FBW7_1	0.2778
p.R25Q	DO222765	COCA	ICGC	VTPVGS	DEG_SCF_FBW7_1	0.2778
p.R25Q	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	VTPVGS	DEG_SCF_FBW7_1	0.2778
p.R25Q	SIDM00736	Non-Cancerous	GDSC	VTPVGS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6KB66	Keratin, type II cytoskeletal 80	DEG_SCF_FBW7_1	18:23	VTPVGS	FBXW7	0.9232	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons