DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 3720:3727

E3 ligase: FBXW7

DEGRON score: 0.7614

ASA_SCORE: 89.4625

COIL: 0.8458

CONS_SCORE: 0.5236

DSS_SCORE: 0.5124

HELIX: 0.0116

FCONS_SCORE: 1

RIG_SCORE: 0.7265

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3717S	TCGA-05-5420	LUAD	TCGA	VTSTPVTT	DEG_SCF_FBW7_1	0.25
p.P3717S	DO26005	LUAD	ICGC	VTSTPVTT	DEG_SCF_FBW7_1	0.25
p.S3715P	TCGA-AJ-A3EL	UCEC	TCGA	VTSTPVTT	DEG_SCF_FBW7_1	0.1944
p.S3715P	DO41542	UCEC	ICGC	VTSTPVTT	DEG_SCF_FBW7_1	0.1944
p.T3721I	TCGA-D3-A2J8	SKCM	TCGA	VTSTPVTT	DEG_SCF_FBW7_1	0.5966
p.T3721I	DO37778	SKCM	ICGC	VTSTPVTT	DEG_SCF_FBW7_1	0.5966
p.P3724H	TCGA-EY-A549	UCEC	TCGA	VTSTPVTT	DEG_SCF_FBW7_1	0.7694
p.P3724H	DO48174	UCEC	ICGC	VTSTPVTT	DEG_SCF_FBW7_1	0.7694
p.E3710K	TCGA-FS-A1ZW	SKCM	TCGA	VTSTPVTT	DEG_SCF_FBW7_1	0.0556
p.E3710K	DO37519	SKCM	ICGC	VTSTPVTT	DEG_SCF_FBW7_1	0.0556
p.S3718Y	TCGA-QS-A5YQ	UCEC	TCGA	VTSTPVTT	DEG_SCF_FBW7_1	0.2778
p.S3718Y	DO49073	UCEC	ICGC	VTSTPVTT	DEG_SCF_FBW7_1	0.2778
p.P3717H	TCGA-UB-A7MB	LIHC	TCGA	VTSTPVTT	DEG_SCF_FBW7_1	0.25
p.P3717H	DO52318	LIHC	ICGC	VTSTPVTT	DEG_SCF_FBW7_1	0.25
p.P3717T	DO228950	LICA	ICGC	VTSTPVTT	DEG_SCF_FBW7_1	0.25
p.S3712I	ACH-001685	Lymphoma	CCLE	VTSTPVTT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3720:3727	VTSTPVTT	FBXW7	0.7614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons