DegronMD

Uniprot ID: Q99102

Source protein: Mucin-4

Source gene: MUC4

Class: DEG_SCF_FBW7_1

Location: 664:670

E3 ligase: FBXW7

DEGRON score: 0.9926

ASA_SCORE: 80.3143

COIL: 0.8413

CONS_SCORE: 0.3701

DSS_SCORE: 0.6446

HELIX: 0.0146

FCONS_SCORE: 0.9765

RIG_SCORE: 0.6433

Degron related mutations and impact score

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W669R	DO228574	LICA	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.8634
p.S669F	TCGA-EE-A3JA	SKCM	TCGA	VTTPGSS	DEG_SCF_FBW7_1	0.6871
p.S669F	DO47625	SKCM	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.6871
p.S669Y	TCGA-37-A5EM	LUSC	TCGA	VTTPGSS	DEG_SCF_FBW7_1	0.6009
p.S669Y	DO223719	LUSC	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.6009
p.E671K	DO223719	LUSC	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.3056
p.T661N	SIDM00789	Colorectal Carcinoma	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.25
p.T661N	ACH-000997	Colon/Colorectal Cancer	CCLE	VTTPGSS	DEG_SCF_FBW7_1	0.25
p.T661N	HCT-15	large_intestine	COSMIC	VTTPGSS	DEG_SCF_FBW7_1	0.25
p.S675P	DO49666	LIAD	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.1944
p.T659A	SIDM00120	Prostate Carcinoma	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1944
p.T659A	ACH-000979	Prostate Cancer	CCLE	VTTPGSS	DEG_SCF_FBW7_1	0.1944
p.T659A	DU-145	prostate	COSMIC	VTTPGSS	DEG_SCF_FBW7_1	0.1944
p.N676D	DO35424	PACA	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.1667
p.N676K	DO43755	UCEC	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.1667
p.A658V	MDA-MB-330	breast	COSMIC	VTTPGSS	DEG_SCF_FBW7_1	0.1667
p.S656C	TCGA-CQ-6221	HNSC	TCGA	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656C	DO14622	HNSC	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656Y	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656Y	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656Y	SIDM00287	B-Lymphoblastic Leukemia	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656Y	SIDM00251	Gastric Carcinoma	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656Y	SIDM00247	Gastric Carcinoma	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656Y	SIDM01498	Acute Myeloid Leukemia	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.D678N	ACH-000971	Colon/Colorectal Cancer	CCLE	VTTPGSS	DEG_SCF_FBW7_1	0.1111

Showing 1 to 25 of 33 entries

Previous1 2Next

Drug responses associated with MUC4 mutations

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

PreviousNext

All proteins holding degron of VTTPGSS

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99102	Mucin-4	DEG_SCF_FBW7_1	664:670	VTTPGSS	FBXW7	0.9926	More...

Showing 1 to 1 of 1 entries

Previous1Next

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTTPGSS

Degron related mutations and impact score

Drug responses associated with MUC4 mutations

All proteins holding degron of VTTPGSS