DegronMD

Uniprot ID: Q99102

Source protein: Mucin-4

Source gene: MUC4

Class: DEG_SCF_FBW7_1

Location: 664:670

E3 ligase: FBXW7

DEGRON score: 0.9926

ASA_SCORE: 80.3143

COIL: 0.8413

CONS_SCORE: 0.3701

DSS_SCORE: 0.6446

HELIX: 0.0146

FCONS_SCORE: 0.9765

RIG_SCORE: 0.6433

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S669Y	TCGA-37-A5EM	LUSC	TCGA	VTTPGSS	DEG_SCF_FBW7_1	0.6009
p.S669Y	DO223719	LUSC	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.6009
p.S656C	TCGA-CQ-6221	HNSC	TCGA	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656C	DO14622	HNSC	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S669F	TCGA-EE-A3JA	SKCM	TCGA	VTTPGSS	DEG_SCF_FBW7_1	0.6871
p.S669F	DO47625	SKCM	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.6871
p.V655I	TCGA-VS-A8EH	CESC	TCGA	VTTPGSS	DEG_SCF_FBW7_1	0.0833
p.V655I	DO222574	BTCA	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.0833
p.V655I	DO51620	CESC	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.0833
p.V655I	DO228088	EOPC	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.0833
p.V655I	DO234199	ESAD	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.0833
p.S675P	DO49666	LIAD	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.1944
p.W669R	DO228574	LICA	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.8634
p.E671K	DO223719	LUSC	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.3056
p.N676D	DO35424	PACA	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.1667
p.N676K	DO43755	UCEC	ICGC	VTTPGSS	DEG_SCF_FBW7_1	0.1667
p.T659A	SIDM00120	Prostate Carcinoma	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1944
p.T659A	ACH-000979	Prostate Cancer	CCLE	VTTPGSS	DEG_SCF_FBW7_1	0.1944
p.T659A	DU-145	prostate	COSMIC	VTTPGSS	DEG_SCF_FBW7_1	0.1944
p.T661N	SIDM00789	Colorectal Carcinoma	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.25
p.T661N	ACH-000997	Colon/Colorectal Cancer	CCLE	VTTPGSS	DEG_SCF_FBW7_1	0.25
p.T661N	HCT-15	large_intestine	COSMIC	VTTPGSS	DEG_SCF_FBW7_1	0.25
p.S656Y	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656Y	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656Y	SIDM00287	B-Lymphoblastic Leukemia	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656Y	SIDM00251	Gastric Carcinoma	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656Y	SIDM00247	Gastric Carcinoma	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.S656Y	SIDM01498	Acute Myeloid Leukemia	GDSC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.D678N	ACH-000971	Colon/Colorectal Cancer	CCLE	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.D678N	HCT-116	large_intestine	COSMIC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.T656A	ACH-000999	Colon/Colorectal Cancer	CCLE	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.T656A	SNU-1040	large_intestine	COSMIC	VTTPGSS	DEG_SCF_FBW7_1	0.1111
p.A658V	MDA-MB-330	breast	COSMIC	VTTPGSS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTTPGSS

Degron related mutations and impact score

Drug responses associated with MUC4 mutations

All proteins holding degron of VTTPGSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99102	Mucin-4	DEG_SCF_FBW7_1	664:670	VTTPGSS	FBXW7	0.9926	More...