DegronMD

Uniprot ID: Q9NSC2

Source protein: Sal-like protein 1

Source gene: SALL1

Class: DEG_SCF_FBW7_2

Location: 348:354

E3 ligase: FBXW7

DEGRON score: 0.9525

ASA_SCORE: 75.8429

COIL: 0.6086

CONS_SCORE: 0.3972

DSS_SCORE: 0.4093

HELIX: 0.2064

FCONS_SCORE: 1.0466

RIG_SCORE: 0.6996

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V356L	TCGA-50-5930	LUAD	TCGA	VTTPSSE	DEG_SCF_FBW7_2	0.2778
p.V356L	DO25189	LUAD	ICGC	VTTPSSE	DEG_SCF_FBW7_2	0.2778
p.A346V	TCGA-AA-3967	COAD	TCGA	VTTPSSE	DEG_SCF_FBW7_2	0.2778
p.A346V	DO10124	COAD	ICGC	VTTPSSE	DEG_SCF_FBW7_2	0.2778
p.A346V	SIDM01953	Colorectal Carcinoma	GDSC	VTTPSSE	DEG_SCF_FBW7_2	0.2778
p.P351L	TCGA-AJ-A3EK	UCEC	TCGA	VTTPSSE	DEG_SCF_FBW7_2	0.7582
p.P351L	DO41584	UCEC	ICGC	VTTPSSE	DEG_SCF_FBW7_2	0.7582
p.P351L	SIDM00449	B-Lymphoblastic Leukemia	GDSC	VTTPSSE	DEG_SCF_FBW7_2	0.7582
p.P351L	ACH-000922	Leukemia	CCLE	VTTPSSE	DEG_SCF_FBW7_2	0.7582
p.P351L	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	VTTPSSE	DEG_SCF_FBW7_2	0.7582
p.P351Q	TCGA-DX-A7EF	SARC	TCGA	VTTPSSE	DEG_SCF_FBW7_2	0.7035
p.P351Q	DO220021	SARC	ICGC	VTTPSSE	DEG_SCF_FBW7_2	0.7035
p.P351S	TCGA-EB-A41B	SKCM	TCGA	VTTPSSE	DEG_SCF_FBW7_2	0.6752
p.P351S	DO37611	SKCM	ICGC	VTTPSSE	DEG_SCF_FBW7_2	0.6752
p.I343T	TCGA-EJ-7315	PRAD	TCGA	VTTPSSE	DEG_SCF_FBW7_2	0.1944
p.I343T	DO36259	PRAD	ICGC	VTTPSSE	DEG_SCF_FBW7_2	0.1944
p.V348I	TCGA-IQ-A6SH	HNSC	TCGA	VTTPSSE	DEG_SCF_FBW7_2	0.5965
p.V348I	DO223268	HNSC	ICGC	VTTPSSE	DEG_SCF_FBW7_2	0.5965
p.M341I	TCGA-KK-A6E6	PRAD	TCGA	VTTPSSE	DEG_SCF_FBW7_2	0.1389
p.M341I	DO51361	PRAD	ICGC	VTTPSSE	DEG_SCF_FBW7_2	0.1389
p.N342T	DO232224	PBCA	ICGC	VTTPSSE	DEG_SCF_FBW7_2	0.1667
p.V348A	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VTTPSSE	DEG_SCF_FBW7_2	0.6936
p.V348A	ACH-000960	Leukemia	CCLE	VTTPSSE	DEG_SCF_FBW7_2	0.6936
p.V348A	REH	haematopoietic_and_lymphoid_tissue	COSMIC	VTTPSSE	DEG_SCF_FBW7_2	0.6936
p.A346G	ACH-000784	Esophageal Cancer	CCLE	VTTPSSE	DEG_SCF_FBW7_2	0.2778
p.C357R	HCT-15	large_intestine	COSMIC	VTTPSSE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSC2	Sal-like protein 1	DEG_SCF_FBW7_2	348:354	VTTPSSE	FBXW7	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTTPSSE

Degron related mutations and impact score

Drug responses associated with SALL1 mutations

All proteins holding degron of VTTPSSE