DegronMD

Uniprot ID: Q6UB99

Source protein: Ankyrin repeat domain-containing protein 11

Source gene: ANKRD11

Class: DEG_SCF_FBW7_2

Location: 1873:1880

E3 ligase: FBXW7

DEGRON score: 0.9891

ASA_SCORE: 91.925

COIL: 0.9271

CONS_SCORE: 0.2998

DSS_SCORE: 0.3378

HELIX: 0.0156

FCONS_SCORE: 0.8915

RIG_SCORE: 0.7158

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1864T	TCGA-2W-A8YY	CESC	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	0.0833
p.A1864T	DO223732	CESC	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	0.0833
p.S1878P	TCGA-A6-5667	COAD	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	0.6752
p.S1878P	DO9868	COAD	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	0.6752
p.P1869L	TCGA-AJ-A3EK	UCEC	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	0.2222
p.P1869L	DO41584	UCEC	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	0.2222
p.K1889E	TCGA-BR-4361	STAD	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	0.1944
p.K1889E	DO38887	STAD	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	0.1944
p.K1889E	SIDM00588	Oral Cavity Carcinoma	GDSC	VTVTPSPE	DEG_SCF_FBW7_2	0.1944
p.K1889E	SIDM01199	Hepatocellular Carcinoma	GDSC	VTVTPSPE	DEG_SCF_FBW7_2	0.1944
p.K1889E	SIDM00292	Small Cell Lung Carcinoma	GDSC	VTVTPSPE	DEG_SCF_FBW7_2	0.1944
p.K1889E	SIDM00469	Pancreatic Carcinoma	GDSC	VTVTPSPE	DEG_SCF_FBW7_2	0.1944
p.K1889E	SIDM01433	Kidney Carcinoma	GDSC	VTVTPSPE	DEG_SCF_FBW7_2	0.1944
p.K1889E	PSN1	pancreas	COSMIC	VTVTPSPE	DEG_SCF_FBW7_2	0.1944
p.K1889E	LU-165	lung	COSMIC	VTVTPSPE	DEG_SCF_FBW7_2	0.1944
p.K1889E	SNU-423	liver	COSMIC	VTVTPSPE	DEG_SCF_FBW7_2	0.1944
p.D1863G	TCGA-DX-AB2Q	SARC	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	0.0556
p.D1863G	DO220087	SARC	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	0.0556
p.D1863N	TCGA-EO-A22R	UCEC	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	0.0556
p.D1863N	DO42713	UCEC	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	0.0556
p.P1877S	TCGA-XK-AAIW	PRAD	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	0.6752
p.P1877S	DO51407	PRAD	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	0.6752
p.H1866P	DO48386	BLCA	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	0.1389
p.E1880K	DO233828	GACA	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	0.7022
p.P1869Q	DO228971	LICA	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	0.2222
p.D1863E	DO229015	LICA	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	0.0556
p.P1877Q	DO229045	LICA	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	0.7035

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SCF_FBW7_2	1873:1880	VTVTPSPE	FBXW7	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTVTPSPE

Degron related mutations and impact score

Drug responses associated with ANKRD11 mutations

All proteins holding degron of VTVTPSPE