DegronMD

Uniprot ID: Q9NVT9

Source protein: Armadillo repeat-containing protein 1

Source gene: ARMC1

Class: LIG_APCC_ABBA_1

Location: 145:150

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6063

ASA_SCORE: 25.4667

COIL: 0.1748

CONS_SCORE: 0.6298

DSS_SCORE: 0.2625

HELIX: 0.0132

FCONS_SCORE: 1.1968

RIG_SCORE: 0.871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D154Y	TCGA-06-5416	GBM	TCGA	VVLHID	LIG_APCC_ABBA_1	0.2222
p.D154Y	DO10880	GBM	ICGC	VVLHID	LIG_APCC_ABBA_1	0.2222
p.I149M	TCGA-39-5021	LUSC	TCGA	VVLHID	LIG_APCC_ABBA_1	0.6507
p.I149M	DO27397	LUSC	ICGC	VVLHID	LIG_APCC_ABBA_1	0.6507
p.G136V	TCGA-D1-A176	UCEC	TCGA	VVLHID	LIG_APCC_ABBA_1	0.0833
p.G136V	DO43947	UCEC	ICGC	VVLHID	LIG_APCC_ABBA_1	0.0833
p.T137S	DO48398	BLCA	ICGC	VVLHID	LIG_APCC_ABBA_1	0.5556
p.E143K	DO222937	BTCA	ICGC	VVLHID	LIG_APCC_ABBA_1	0.2778
p.R155Q	DO222755	COCA	ICGC	VVLHID	LIG_APCC_ABBA_1	0.1944
p.T138A	DO233220	GACA	ICGC	VVLHID	LIG_APCC_ABBA_1	0.5833
p.T138A	DO229208	THCA	ICGC	VVLHID	LIG_APCC_ABBA_1	0.5833
p.P136S	DO233888	GACA	ICGC	VVLHID	LIG_APCC_ABBA_1	0.0833
p.N139S	DO231958	LICA	ICGC	VVLHID	LIG_APCC_ABBA_1	0.1667
p.H148N	DO229024	LICA	ICGC	VVLHID	LIG_APCC_ABBA_1	0.7423
p.T137N	DO229024	LICA	ICGC	VVLHID	LIG_APCC_ABBA_1	0.5556
p.A142D	DO229009	LICA	ICGC	VVLHID	LIG_APCC_ABBA_1	0.25
p.Q149H	DO43202	UCEC	ICGC	VVLHID	LIG_APCC_ABBA_1	0.7582
p.A152V	DO41572	UCEC	ICGC	VVLHID	LIG_APCC_ABBA_1	0.2778
p.H148R	SIDM00189	Melanoma	GDSC	VVLHID	LIG_APCC_ABBA_1	0.8244
p.H148R	ACH-002098	Skin Cancer	CCLE	VVLHID	LIG_APCC_ABBA_1	0.8244
p.H148R	CP67-MEL	skin	COSMIC	VVLHID	LIG_APCC_ABBA_1	0.8244
p.T155M	SIDM00839	Colorectal Carcinoma	GDSC	VVLHID	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVT9	Armadillo repeat-containing protein 1	LIG_APCC_ABBA_1	145:150	VVLHID	APC,CDC20,FZR1	0.6063	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons