DegronMD - Q9NVT9(ARMC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D154Y	TCGA-06-5416	GBM	TCGA	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2222
p.D154Y	DO10880	GBM	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2222
p.I149M	TCGA-39-5021	LUSC	TCGA	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.6507
p.I149M	DO27397	LUSC	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.6507
p.T227I	TCGA-AB-2807	LAML	TCGA	LVPFQD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.3056
p.V231A	TCGA-CG-4460	STAD	TCGA	LVPFQD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.1944
p.G136V	TCGA-D1-A176	UCEC	TCGA	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0833
p.G136V	DO43947	UCEC	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0833
p.T137S	DO48398	BLCA	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation blocking phosphorylation signal	0.5556
p.E143K	DO222937	BTCA	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2778
p.R155Q	DO222755	COCA	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1944
p.T138A	DO233220	GACA	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation blocking phosphorylation signal	0.5833
p.T138A	DO229208	THCA	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation blocking phosphorylation signal	0.5833
p.P136S	DO233888	GACA	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0833
p.N139S	DO231958	LICA	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1667
p.H148N	DO229024	LICA	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.7423
p.T137N	DO229024	LICA	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation blocking phosphorylation signal	0.5556
p.A142D	DO229009	LICA	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.25
p.Q149H	DO43202	UCEC	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.7582
p.A152V	DO41572	UCEC	ICGC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2778
p.H148R	SIDM00189	Melanoma	GDSC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.8244
p.H148R	ACH-002098	Skin Cancer	CCLE	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.8244
p.H148R	CP67-MEL	skin	COSMIC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.8244
p.T155M	SIDM00839	Colorectal Carcinoma	GDSC	VVLHID	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1944
p.N234T	ACH-001991	Primary	CCLE	LVPFQD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.1111

Kaplan plot for ARMC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARMC1

UniProt ID: Q9NVT9

Entrez ID: 55156

Protein name: Armadillo repeat-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARMC1 in