DegronMD

Uniprot ID: P03971

Source protein: Muellerian-inhibiting factor

Source gene: AMH

Class: LIG_APCC_ABBA_1

Location: 131:136

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6211

ASA_SCORE: 43.95

COIL: 0.2147

CONS_SCORE: 0.5203

DSS_SCORE: 0.3516

HELIX: 0.0758

FCONS_SCORE: 1.3521

RIG_SCORE: 0.8342

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R123Q	SIDM00353	Other Sarcomas	GDSC	VVLHLE	LIG_APCC_ABBA_1	0.1111
p.R123Q	SIDM00571	Pancreatic Carcinoma	GDSC	VVLHLE	LIG_APCC_ABBA_1	0.1111
p.R123Q	SIDM00587	Biliary Tract Carcinoma	GDSC	VVLHLE	LIG_APCC_ABBA_1	0.1111
p.R123Q	SIDM01449	Pancreatic Carcinoma	GDSC	VVLHLE	LIG_APCC_ABBA_1	0.1111
p.P142S	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VVLHLE	LIG_APCC_ABBA_1	0.1667
p.P142S	ACH-001669	Leukemia	CCLE	VVLHLE	LIG_APCC_ABBA_1	0.1667
p.P142S	ACH-002238	Leukemia	CCLE	VVLHLE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P03971	Muellerian-inhibiting factor	LIG_APCC_ABBA_1	131:136	VVLHLE	APC,CDC20,FZR1	0.6211	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons