DegronMD

Uniprot ID: Q96H15

Source protein: T-cell immunoglobulin and mucin domain-containing protein 4

Source gene: TIMD4

Class: DEG_SCF_FBW7_1

Location: 171:178

E3 ligase: FBXW7

DEGRON score: 0.9603

ASA_SCORE: 85.4625

COIL: 0.8249

CONS_SCORE: 0.4728

DSS_SCORE: 0.5077

HELIX: 0.0285

FCONS_SCORE: 1.1519

RIG_SCORE: 0.8195

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V172L	TCGA-17-Z031	LUAD	TCGA	VVTTPDLT	DEG_SCF_FBW7_1	0.5654
p.P164L	TCGA-78-7146	LUAD	TCGA	VVTTPDLT	DEG_SCF_FBW7_1	0.1389
p.P164L	DO23717	LUAD	ICGC	VVTTPDLT	DEG_SCF_FBW7_1	0.1389
p.D176N	TCGA-AP-A1DV	UCEC	TCGA	VVTTPDLT	DEG_SCF_FBW7_1	0.5821
p.D176N	DO43186	UCEC	ICGC	VVTTPDLT	DEG_SCF_FBW7_1	0.5821
p.G180R	TCGA-AX-A3FT	UCEC	TCGA	VVTTPDLT	DEG_SCF_FBW7_1	0.2778
p.G180R	DO40801	UCEC	ICGC	VVTTPDLT	DEG_SCF_FBW7_1	0.2778
p.G180R	SIDM00449	B-Lymphoblastic Leukemia	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.2778
p.G180R	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.2778
p.L183I	TCGA-D1-A103	UCEC	TCGA	VVTTPDLT	DEG_SCF_FBW7_1	0.1944
p.L183I	DO42312	UCEC	ICGC	VVTTPDLT	DEG_SCF_FBW7_1	0.1944
p.P168S	TCGA-EE-A2GJ	SKCM	TCGA	VVTTPDLT	DEG_SCF_FBW7_1	0.25
p.P168S	TCGA-ER-A193	SKCM	TCGA	VVTTPDLT	DEG_SCF_FBW7_1	0.25
p.P168S	DO37746	SKCM	ICGC	VVTTPDLT	DEG_SCF_FBW7_1	0.25
p.P168S	DO47368	SKCM	ICGC	VVTTPDLT	DEG_SCF_FBW7_1	0.25
p.P175L	TCGA-FR-A7U9	SKCM	TCGA	VVTTPDLT	DEG_SCF_FBW7_1	0.7582
p.P175L	DO48546	SKCM	ICGC	VVTTPDLT	DEG_SCF_FBW7_1	0.7582
p.P164S	TCGA-FW-A3R5	SKCM	TCGA	VVTTPDLT	DEG_SCF_FBW7_1	0.1389
p.P164S	DO37406	SKCM	ICGC	VVTTPDLT	DEG_SCF_FBW7_1	0.1389
p.P168Q	DO229008	LICA	ICGC	VVTTPDLT	DEG_SCF_FBW7_1	0.25
p.V172M	DO231072	LUSC	ICGC	VVTTPDLT	DEG_SCF_FBW7_1	0.6097
p.V172M	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.6097
p.T173A	DO232761	PBCA	ICGC	VVTTPDLT	DEG_SCF_FBW7_1	0.6028
p.T162A	SIDM01090	Colorectal Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.0833
p.T162A	ACH-000943	Colon/Colorectal Cancer	CCLE	VVTTPDLT	DEG_SCF_FBW7_1	0.0833
p.T162A	RKO	large_intestine	COSMIC	VVTTPDLT	DEG_SCF_FBW7_1	0.0833
p.T179I	SIDM00855	Other Sarcomas	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T179I	SIDM00656	Burkitt's Lymphoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T179I	SIDM00633	Breast Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T179I	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T179I	SIDM00254	Neuroblastoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T179I	SIDM00844	Burkitt's Lymphoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T179I	SIDM01133	Other Solid Cancers	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T179I	SIDM01229	Neuroblastoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T179I	SIDM00641	Burkitt's Lymphoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T179I	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00855	Other Sarcomas	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00656	Burkitt's Lymphoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00633	Breast Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00654	Small Cell Lung Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00210	Ovarian Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00878	Breast Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00254	Neuroblastoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00309	Mesothelioma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00844	Burkitt's Lymphoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00032	Bladder Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM01133	Other Solid Cancers	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00863	Burkitt's Lymphoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM01229	Neuroblastoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM00641	Burkitt's Lymphoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM01664	Prostate Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.T170K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.3056
p.V171A	SIDM00660	Colorectal Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.6936
p.V171A	ACH-000985	Colon/Colorectal Cancer	CCLE	VVTTPDLT	DEG_SCF_FBW7_1	0.6936
p.V171A	LS-411N	large_intestine	COSMIC	VVTTPDLT	DEG_SCF_FBW7_1	0.6936
p.P175T	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.7031
p.P175T	SIDM00164	Biliary Tract Carcinoma	GDSC	VVTTPDLT	DEG_SCF_FBW7_1	0.7031
p.P175T	ACH-000209	Bile Duct Cancer	CCLE	VVTTPDLT	DEG_SCF_FBW7_1	0.7031
p.P175T	ACH-002059	Leukemia	CCLE	VVTTPDLT	DEG_SCF_FBW7_1	0.7031
p.P175T	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VVTTPDLT	DEG_SCF_FBW7_1	0.7031
p.P182S	ACH-002069	Bone Cancer	CCLE	VVTTPDLT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVTTPDLT

Degron related mutations and impact score

Drug responses associated with TIMD4 mutations

All proteins holding degron of VVTTPDLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SCF_FBW7_1	171:178	VVTTPDLT	FBXW7	0.9603	More...