DegronMD

Uniprot ID: P11171

Source protein: Protein 4.1

Source gene: EPB41

Class: LIG_APCC_ABBA_1

Location: 853:858

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9739

ASA_SCORE: 81.4333

COIL: 0.222

CONS_SCORE: 0.5452

DSS_SCORE: 0.5733

HELIX: 0.0107

FCONS_SCORE: 1.0538

RIG_SCORE: 0.8094

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E860K	TCGA-A5-A0G2	UCEC	TCGA	VVVHQE	LIG_APCC_ABBA_1	0.2778
p.Q857K	TCGA-D3-A2JC	SKCM	TCGA	VVVHQE	LIG_APCC_ABBA_1	0.5833
p.D863G	SIDM01664	Prostate Carcinoma	GDSC	VVVHQE	LIG_APCC_ABBA_1	0.1944
p.D863G	ACH-000952	Prostate Cancer	CCLE	VVVHQE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11171	Protein 4.1	LIG_APCC_ABBA_1	853:858	VVVHQE	APC,CDC20,FZR1	0.9739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons