DegronMD

Uniprot ID: Q9NUB1

Source protein: Acetyl-coenzyme A synthetase 2-like, mitochondrial

Source gene: ACSS1

Class: DEG_SCF_FBW7_1

Location: 82:89

E3 ligase: FBXW7

DEGRON score: 0.7334

ASA_SCORE: 62.1

COIL: 0.7299

CONS_SCORE: 0.4601

DSS_SCORE: 0.0917

HELIX: 0.0713

FCONS_SCORE: 1.2254

RIG_SCORE: 0.9

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W91L	TCGA-ER-A19P	SKCM	TCGA	VWDTPYHT	DEG_SCF_FBW7_1	0.2778
p.W91L	DO47623	SKCM	ICGC	VWDTPYHT	DEG_SCF_FBW7_1	0.2778
p.L76P	TCGA-F1-6874	STAD	TCGA	VWDTPYHT	DEG_SCF_FBW7_1	0.1667
p.L76P	DO38201	STAD	ICGC	VWDTPYHT	DEG_SCF_FBW7_1	0.1667
p.G98V	SIDM00683	Prostate Carcinoma	GDSC	VWDTPYHT	DEG_SCF_FBW7_1	0.0833
p.G98V	ACH-000977	lymph_node	CCLE	VWDTPYHT	DEG_SCF_FBW7_1	0.0833
p.G98D	SIDM00901	Endometrial Carcinoma	GDSC	VWDTPYHT	DEG_SCF_FBW7_1	0.0833
p.G98D	ACH-000940	Endometrial/Uterine Cancer	CCLE	VWDTPYHT	DEG_SCF_FBW7_1	0.0833
p.G98D	AN3-CA	endometrium	COSMIC	VWDTPYHT	DEG_SCF_FBW7_1	0.0833
p.V90A	ACH-001081	Colon/Colorectal Cancer	CCLE	VWDTPYHT	DEG_SCF_FBW7_1	0.3056
p.V90A	HCC2998	large_intestine	COSMIC	VWDTPYHT	DEG_SCF_FBW7_1	0.3056
p.D84Y	ACH-001623	Brain Cancer	CCLE	VWDTPYHT	DEG_SCF_FBW7_1	0.6214

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NUB1	Acetyl-coenzyme A synthetase 2-like, mitochondrial	DEG_SCF_FBW7_1	82:89	VWDTPYHT	FBXW7	0.7334	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons