DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 1973:1977

E3 ligase: SPOP

DEGRON score: 0.5858

ASA_SCORE: 93.14

COIL: 0.7958

CONS_SCORE: 0

DSS_SCORE: 0.54

HELIX: 0.015

FCONS_SCORE: 0

RIG_SCORE: 0.7831

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1970Q	TCGA-55-8203	LUAD	TCGA	VWTST	DEG_SPOP_SBC_1	0.25
p.P1970Q	DO218928	LUAD	ICGC	VWTST	DEG_SPOP_SBC_1	0.25
p.P1969T	TCGA-AG-3890	READ	TCGA	VWTST	DEG_SPOP_SBC_1	0.2222
p.P1969T	TCGA-BH-A0BP	BRCA	TCGA	VWTST	DEG_SPOP_SBC_1	0.2222
p.P1969T	DO4056	BRCA	ICGC	VWTST	DEG_SPOP_SBC_1	0.2222
p.P1969T	DO36431	READ	ICGC	VWTST	DEG_SPOP_SBC_1	0.2222
p.S1983F	TCGA-G2-A3IB	BLCA	TCGA	VWTST	DEG_SPOP_SBC_1	0.1667
p.S1983F	DO512	BLCA	ICGC	VWTST	DEG_SPOP_SBC_1	0.1667
p.I1980S	TCGA-HU-A4GH	STAD	TCGA	VWTST	DEG_SPOP_SBC_1	0.25
p.I1980S	DO47743	STAD	ICGC	VWTST	DEG_SPOP_SBC_1	0.25
p.I1980T	DO228374	LICA	ICGC	VWTST	DEG_SPOP_SBC_1	0.25
p.H1964Q	SIDM00808	Burkitt's Lymphoma	GDSC	VWTST	DEG_SPOP_SBC_1	0.0833
p.H1964Q	SIDM01254	Burkitt's Lymphoma	GDSC	VWTST	DEG_SPOP_SBC_1	0.0833
p.Q1982H	ACH-000901	Lung Cancer	CCLE	VWTST	DEG_SPOP_SBC_1	0.1944
p.I1980V	ACH-002011	Eye Cancer	CCLE	VWTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1973:1977	VWTST	SPOP	0.5858	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons