DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VYPYKE
Uniprot ID:
Q6ZTR5
Source protein:
Cilia- and flagella-associated protein 47
Source gene:
CFAP47
Class:
LIG_APCC_ABBA_1
Location:
2460:2465
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.961
ASA_SCORE:
80.9333
COIL:
0.7003
CONS_SCORE:
0
DSS_SCORE:
0.015
HELIX:
0.005
FCONS_SCORE:
0
RIG_SCORE:
1.0004
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CFAP47 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VYPYKE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZTR5
Cilia- and flagella-associated protein 47
LIG_APCC_ABBA_1
2460:2465
VYPYKE
APC,CDC20,FZR1
0.961
More...