DegronMD

Uniprot ID: Q6X4W1

Source protein: NMDA receptor synaptonuclear signaling and neuronal migration factor

Source gene: NSMF

Class: DEG_SCF_SKP2-CKS1_1

Location: 291:298

E3 ligase: SKP2,CSK1

DEGRON score: 0.98

ASA_SCORE: 89.35

COIL: 0.924

CONS_SCORE: 0.6108

DSS_SCORE: 0.5597

HELIX: 0.0346

FCONS_SCORE: 1.1243

RIG_SCORE: 0.6153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S308I	TCGA-33-6738	LUSC	TCGA	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R289Q	TCGA-BR-4362	STAD	TCGA	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.2778
p.D304G	TCGA-FI-A2D5	UCEC	TCGA	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E307Q	DO233925	GACA	ICGC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.0833
p.W304C	DO20917	KIRP	ICGC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P281L	DO37406	SKCM	ICGC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.0556
p.L302P	DO47957	STAD	ICGC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.6667
p.S285N	DO229232	THCA	ICGC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R289W	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R289W	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R287W	ACH-000271	Lymphoma	CCLE	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R287W	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T295P	HCC-366	lung	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.7031
p.T287M	786-0	kidney	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.2222
p.E295K	SNU-1040	large_intestine	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.7022
p.T293P	HCC-366	lung	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.7031
p.T294M	786-0	kidney	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.7423
p.E297K	SNU-1040	large_intestine	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.7022
p.E290K	SNU-1040	large_intestine	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.3056
p.T292M	786-0	kidney	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6X4W1	NMDA receptor synaptonuclear signaling and neuronal migration factor	DEG_SCF_SKP2-CKS1_1	291:298	WSDPTPMK	SKP2,CSK1	0.98	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons