DegronMD

Uniprot ID: Q9HCM2

Source protein: Plexin-A4

Source gene: PLXNA4

Class: DEG_APCC_KENBOX_2

Location: 122:126

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.732

ASA_SCORE: 103.14

COIL: 0.773

CONS_SCORE: 0.4698

DSS_SCORE: 0.0374

HELIX: 0.0204

FCONS_SCORE: 0.7745

RIG_SCORE: 0.9515

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L119V	TCGA-44-5644	LUAD	TCGA	YKENR	DEG_APCC_KENBOX_2	0.25
p.L119V	DO25153	LUAD	ICGC	YKENR	DEG_APCC_KENBOX_2	0.25
p.K123N	TCGA-AX-A06F	UCEC	TCGA	YKENR	DEG_APCC_KENBOX_2	0.6918
p.K123N	DO41752	UCEC	ICGC	YKENR	DEG_APCC_KENBOX_2	0.6918
p.N112S	TCGA-B5-A0JY	UCEC	TCGA	YKENR	DEG_APCC_KENBOX_2	0.0556
p.N112S	DO43041	UCEC	ICGC	YKENR	DEG_APCC_KENBOX_2	0.0556
p.E124D	TCGA-D1-A16X	UCEC	TCGA	YKENR	DEG_APCC_KENBOX_2	0.6758
p.E124D	DO41799	UCEC	ICGC	YKENR	DEG_APCC_KENBOX_2	0.6758
p.Y134H	TCGA-DI-A1BU	UCEC	TCGA	YKENR	DEG_APCC_KENBOX_2	0.1111
p.Y134H	DO42023	UCEC	ICGC	YKENR	DEG_APCC_KENBOX_2	0.1111
p.N115D	TCGA-DI-A1BU	UCEC	TCGA	YKENR	DEG_APCC_KENBOX_2	0.1389
p.N115D	DO42023	UCEC	ICGC	YKENR	DEG_APCC_KENBOX_2	0.1389
p.L119I	TCGA-EE-A2MJ	SKCM	TCGA	YKENR	DEG_APCC_KENBOX_2	0.25
p.L119I	DO38099	SKCM	ICGC	YKENR	DEG_APCC_KENBOX_2	0.25
p.Y122C	TCGA-EJ-5509	PRAD	TCGA	YKENR	DEG_APCC_KENBOX_2	0.5976
p.Y122C	DO36255	PRAD	ICGC	YKENR	DEG_APCC_KENBOX_2	0.5976
p.K116N	TCGA-IB-7651	PAAD	TCGA	YKENR	DEG_APCC_KENBOX_2	0.2778
p.K116N	DO46657	PAAD	ICGC	YKENR	DEG_APCC_KENBOX_2	0.2778
p.V114I	DO233764	GACA	ICGC	YKENR	DEG_APCC_KENBOX_2	0.1111
p.G136S	DO233294	NACA	ICGC	YKENR	DEG_APCC_KENBOX_2	0.0556
p.E124G	SIDM00660	Colorectal Carcinoma	GDSC	YKENR	DEG_APCC_KENBOX_2	0.7199
p.E124G	ACH-000985	Colon/Colorectal Cancer	CCLE	YKENR	DEG_APCC_KENBOX_2	0.7199
p.E124G	LS-411N	large_intestine	COSMIC	YKENR	DEG_APCC_KENBOX_2	0.7199
p.N113S	SIDM01154	T-Lymphoblastic Leukemia	GDSC	YKENR	DEG_APCC_KENBOX_2	0.0833
p.N113S	ACH-000953	Leukemia	CCLE	YKENR	DEG_APCC_KENBOX_2	0.0833
p.N113S	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	YKENR	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCM2	Plexin-A4	DEG_APCC_KENBOX_2	122:126	YKENR	APC,CDC20,FZR1	0.732	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: YKENR

Degron related mutations and impact score

Drug responses associated with PLXNA4 mutations

All proteins holding degron of YKENR