DegronMD

Uniprot ID: Q00839

Source protein: Heterogeneous nuclear ribonucleoprotein U

Source gene: HNRNPU

Class: DEG_SIAH_1

Location: 753:761

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.996

ASA_SCORE: 75.1556

COIL: 0.9548

CONS_SCORE: 0.386

DSS_SCORE: 0.4919

HELIX: 0.018

FCONS_SCORE: 0.8522

RIG_SCORE: 0.7126

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G763V	TCGA-23-2649	OV	TCGA	YPRAPVFPG	DEG_SIAH_1	0.2778
p.G763V	DO31779	OV	ICGC	YPRAPVFPG	DEG_SIAH_1	0.2778
p.G744V	TCGA-55-8299	LUAD	TCGA	YPRAPVFPG	DEG_SIAH_1	0.0833
p.G744V	DO25927	LUAD	ICGC	YPRAPVFPG	DEG_SIAH_1	0.0833
p.G745R	TCGA-CR-7402	HNSC	TCGA	YPRAPVFPG	DEG_SIAH_1	0.1111
p.G745R	DO15727	HNSC	ICGC	YPRAPVFPG	DEG_SIAH_1	0.1111
p.P757L	TCGA-L5-A4OP	ESCA	TCGA	YPRAPVFPG	DEG_SIAH_1	0.6471
p.Y765H	TCGA-MH-A562	KIRP	TCGA	YPRAPVFPG	DEG_SIAH_1	0.2222
p.Y765H	DO48495	KIRP	ICGC	YPRAPVFPG	DEG_SIAH_1	0.2222
p.G750S	DO222455	ESCA	ICGC	YPRAPVFPG	DEG_SIAH_1	0.25
p.G750S	DO232761	PBCA	ICGC	YPRAPVFPG	DEG_SIAH_1	0.25
p.A756S	DO228917	LICA	ICGC	YPRAPVFPG	DEG_SIAH_1	0.7588
p.R755S	DO229027	LICA	ICGC	YPRAPVFPG	DEG_SIAH_1	0.6316
p.R755S	DO231201	LUSC	ICGC	YPRAPVFPG	DEG_SIAH_1	0.6316
p.R762C	DO229052	LICA	ICGC	YPRAPVFPG	DEG_SIAH_1	0.3056
p.Y765S	DO220850	MELA	ICGC	YPRAPVFPG	DEG_SIAH_1	0.2222
p.G761D	DO229213	THCA	ICGC	YPRAPVFPG	DEG_SIAH_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00839	Heterogeneous nuclear ribonucleoprotein U	DEG_SIAH_1	753:761	YPRAPVFPG	SIAH1,SIAH2,SIAH3	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons