DegronMD

Uniprot ID: Q9P2W1

Source protein: Homologous-pairing protein 2 homolog

Source gene: PSMC3IP

Class: DEG_APCC_DBOX_1

Location: 140:148

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.502

ASA_SCORE: 96.6889

COIL: 0.0791

CONS_SCORE: 0.627

DSS_SCORE: 0.4028

HELIX: 0.9214

FCONS_SCORE: 1.0202

RIG_SCORE: 0.7695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A138T	TCGA-AX-A1CE	UCEC	TCGA	YRERLKNIK	DEG_APCC_DBOX_1	0.2778
p.A138T	TCGA-EO-A22U	UCEC	TCGA	YRERLKNIK	DEG_APCC_DBOX_1	0.2778
p.H153R	TCGA-DU-6392	LGG	TCGA	YRERLKNIK	DEG_APCC_DBOX_1	0.1944
p.E142Q	TCGA-HQ-A5NE	BLCA	TCGA	YRERLKNIK	DEG_APCC_DBOX_1	0.5633
p.G140A	DO224662	BRCA	ICGC	YRERLKNIK	DEG_APCC_DBOX_1	0.754
p.T143M	DO223732	CESC	ICGC	YRERLKNIK	DEG_APCC_DBOX_1	0.7423
p.T143M	DO48016	STAD	ICGC	YRERLKNIK	DEG_APCC_DBOX_1	0.7423
p.T143M	IST-SL1	lung	COSMIC	YRERLKNIK	DEG_APCC_DBOX_1	0.7423
p.N148T	DO220201	SARC	ICGC	YRERLKNIK	DEG_APCC_DBOX_1	0.7055
p.V149I	DO38495	STAD	ICGC	YRERLKNIK	DEG_APCC_DBOX_1	0.3056
p.V149I	DO47717	STAD	ICGC	YRERLKNIK	DEG_APCC_DBOX_1	0.3056
p.V149I	DO43306	UCEC	ICGC	YRERLKNIK	DEG_APCC_DBOX_1	0.3056
p.V149I	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	YRERLKNIK	DEG_APCC_DBOX_1	0.3056
p.K133Q	DO39016	THCA	ICGC	YRERLKNIK	DEG_APCC_DBOX_1	0.1389
p.F136C	DO52412	UCEC	ICGC	YRERLKNIK	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2W1	Homologous-pairing protein 2 homolog	DEG_APCC_DBOX_1	140:148	YRERLKNIK	APC,CDC20,FZR1	0.502	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons