DegronMD

Uniprot ID: Q9NUQ7

Source protein: Ufm1-specific protease 2

Source gene: UFSP2

Class: DEG_APCC_DBOX_1

Location: 226:234

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5884

ASA_SCORE: 54.2222

COIL: 0.1077

CONS_SCORE: 0.4915

DSS_SCORE: 0.3321

HELIX: 0.8912

FCONS_SCORE: 1.1627

RIG_SCORE: 0.8045

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H238N	TCGA-BT-A20Q	BLCA	TCGA	YRKELHDLF	DEG_APCC_DBOX_1	0.2222
p.H238N	DO695	BLCA	ICGC	YRKELHDLF	DEG_APCC_DBOX_1	0.2222
p.D239N	TCGA-EI-6917	READ	TCGA	YRKELHDLF	DEG_APCC_DBOX_1	0.1944
p.D239N	TCGA-FI-A2D5	UCEC	TCGA	YRKELHDLF	DEG_APCC_DBOX_1	0.1944
p.D239N	DO36881	READ	ICGC	YRKELHDLF	DEG_APCC_DBOX_1	0.1944
p.D239N	DO41331	UCEC	ICGC	YRKELHDLF	DEG_APCC_DBOX_1	0.1944
p.H238P	DO50785	LIRI	ICGC	YRKELHDLF	DEG_APCC_DBOX_1	0.2222
p.D239Y	DO50785	LIRI	ICGC	YRKELHDLF	DEG_APCC_DBOX_1	0.1944
p.G221C	SIDM00396	Acute Myeloid Leukemia	GDSC	YRKELHDLF	DEG_APCC_DBOX_1	0.1944
p.G221C	ACH-000112	Leukemia	CCLE	YRKELHDLF	DEG_APCC_DBOX_1	0.1944
p.G221C	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	YRKELHDLF	DEG_APCC_DBOX_1	0.1944
p.D232Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	YRKELHDLF	DEG_APCC_DBOX_1	0.6214
p.E229D	ACH-001521	Skin Cancer	CCLE	YRKELHDLF	DEG_APCC_DBOX_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NUQ7	Ufm1-specific protease 2	DEG_APCC_DBOX_1	226:234	YRKELHDLF	APC,CDC20,FZR1	0.5884	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons